Isolation and structural elucidation of two novel lignans from the flowers of Gardenia jasminoides with potent α-glucosidase inhibitory activity

被引：0

作者：

Shao, Qingsen ^{[1
]}

Li, Huiyu ^{[1
]}

Li, Mingfeng ^{[2
]}

Yi, Wei ^{[2
]}

Zhou, Qiugui ^{[1
]}

Zheng, Lijuan ^{[1
]}

Wang, Meng ^{[1
]}

Hu, Hong-mei ^{[1
]}

Wen, Chao ^{[1
]}

Tang, Yun ^{[1
]}

Li, Wei ^{[1
]}

机构：

[1] Jinggangshan Univ, Coll Tradit Chinese Med & Pharm, Hlth Sci Ctr, Jiangxi Prov Key Lab Organ Dev & Epigenet, Jian 343009, Peoples R China

[2] Yi Chun Publ Secur Bur, Criminal Sci & Technol Inst, Yichun, Peoples R China

来源：

PHYTOCHEMISTRY LETTERS | 2025年 / 67卷

关键词：

Gardenia jasminoides; Rubiaceae; Lignans; Jasminosides; alpha-glucosidase inhibitory activity;

D O I：

10.1016/j.phytol.2025.102959

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

This research presents the isolation and structural elucidation of two novel lignans, designated as Jasminoside U (1) and Jasminoside W (2), from the flowers of Gardenia jasminoides. The structures of these compounds were determined using a comprehensive analytical approach that included NMR spectroscopy, HR-ESI-MS, and detailed analysis of ROE correlations and coupling constants. Additionally, the alpha-glucosidase inhibitory activities of compounds 1 and 2 were evaluated using a standard enzyme assay protocol. The assay results demonstrated that both Jasminoside U (1) and Jasminoside W (2) possess significant inhibitory effects on alpha-glucosidase, with IC50 values determined to be 266 and 323 mu mol/L, respectively, indicating their potential as therapeutic agents for the treatment of diabetes and related metabolic disorders.

引用

页数：5

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