Role of exosomes in pathogenesis, diagnosis, and treatment of diabetic nephropathy

被引：0

作者：

Shaimaa I. Barr ^{[1
]}

Eman M. Abd El-Azeem ^{[1
]}

Sahar S. Bessa ^{[2
]}

Tarek M. Mohamed ^{[3
]}

机构：

[1] Ain Shams University,Biochemistry Department, Faculty of Science

[2] Tanta University,Internal Medicine Department, Faculty of Medicine

[3] Tanta University,Biochemistry Division, Chemistry Department, Faculty of Science

来源：

BMC Nephrology | / 26卷 / 1期

关键词：

Diabetic nephropathy; Exosomes; Biomarker; Pathogenesis; Therapeutic strategies;

D O I：

10.1186/s12882-025-04120-4

中图分类号：

学科分类号：

摘要：

Diabetic nephropathy (DN) is a serious microvascular complication that can progress to end-stage renal disease, with its prevalence and associated mortality increasing globally. However extensive research, the precise mechanisms underlying DN pathogenesis remain unclear, and the current treatment options for DN are limited to dialysis or renal replacement therapy, although several experimental approaches have shown potential, they remain investigational and lack clinical translation. Exosomes play a pivotal role in disease diagnosis and prognosis. Urinary exosomes, originating from various kidney cells, reflect the kidney’s pathological condition and are involved in cell-to-cell communication through autocrine or paracrine signaling; therefore, they could contribute to the pathogenesis of DN and potential therapeutic approaches. Additionally, due to their diverse cargo, which depend on cellular origin and pathological state, exosomes may act as biomarkers for the early prediction of DN. This review presents a comprehensive overview of the latest findings on the role of exosomes in the diagnosis, pathogenesis, and treatment of DN.

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