The Role of Prehabilitation in Oncology Patients Undergoing Complex Systemic Anticancer Therapy

Objectives: To review the recent literature around the role of patient-centric prehabilitation for oncology patients undergoing complex systemic anticancer therapy (SACT) and the nurse's role in this area. Method: A narrative review of recent peer-reviewed literature, national guidance, and government strategy for prehabilitation in oncology patients undergoing complex SACT. Results/Conclusion: Prehabilitation interventions in people receiving complex SACT are feasible and benefit patient outcomes. These results must still be viewed with caution; however, as of now, there are only smallscale studies in this area, although larger-scale studies are now being done. The role of the nurse is key here (as part of the interdisciplinary team) through the establishment of the therapeutic relationship underpinning patient screening, assessment, intervention implementation, and patient reassessment, ensuring care is dynamic, consistent, and tailored to patient needs. Implications for Nursing Practice: The review has discussed the beneficial patient outcomes from prehabilitation in patients receiving complex SACT, but more research is warranted in the form of larger multisite trials to increase the validity of the prehabilitation interventions. The review advocates for the role of the nurse in the provision of prehabilitation in SACT oncology patients through the provision of personalized patient care. (c) 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.