Simultaneous Release of Hydrophilic and Hydrophobic Drugs by a pH-sensitive Bio-carrier Based on Layered Double Hydroxides Decorated with l-serine-chitosan

被引：0
作者：
Soheyla Karimi [1 ]
Hassan Namazi [1 ]
Mohammad Aghazadeh [2 ]
机构：
[1] Research Laboratory of Dendrimers and Nanopolymers, Faculty of Chemistry, University of Tabriz, P.O. Box 51666, Tabriz
[2] Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Science, Tabriz
[3] Department of Medical Microbiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz
[4] Immunology Research Center, Tabriz University of Medical Sciences, Tabriz
来源：
Journal of Polymers and the Environment | 2025年 / 33卷 / 6期
基金：
美国国家科学基金会;
关键词：
Bio-carrier; Chitosan; Controlled release; L-serine; Layered double hydroxide; Targeted delivery;
D O I：
10.1007/s10924-025-03560-1
中图分类号：
学科分类号：
摘要：
Recently, the development of pH-responsive carriers has emerged as a promising area of research in cancer treatment. For these reasons, the purpose of the present work is to investigate layered double hydroxides decorated with l-serine-chitosan (LDH-DOX-CUR/Ser-CS) for the targeted release of doxorubicin (DOX, hydrophilic) and curcumin (CUR, hydrophobic) drugs to HepG2 liver cancer cells. Different methods such as FT-IR, FE-SEM, Zeta potential, EDX, and XRD analysis were employed to validate the structural properties of the developed bio-carriers. The encapsulation efficiencies for DOX and CUR were ∼96.8% and ∼83.6%, respectively. The drug release evaluation highlighted the pH-sensitive and controlled release capabilities of the LDH-DOX-CUR/Ser-CS bio-carriers to acidic tumor microenvironments. Both drugs’ release mechanisms also showed compliance with the Fickian diffusion from the Korsmeyer-Peppas model. Additionally, the bioavailability of the designed LDH against both HepG2 (liver cancer cell line) and L929 (normal liver cell line) cells was proved by cytotoxicity test. On the other hand, the LDH-DOX-CUR/Ser-CS bio-carriers exhibited higher cytotoxicity against HepG2 cells, which is caused by the controlled and targeted delivery of both drugs to these cells. The antibacterial, antioxidant, and blood compatibility properties of the engineered bio-carriers were confirmed by relevant in vitro techniques. In general, the results of this study showed that engineered bio-carriers have the necessary potential and efficiency for use as drug delivery bio-carriers in the biomedical field. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2025.
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页码：2758 / 2775
页数：17
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