Synthesis, optimization, and characterization of β-cyclodextrin-based biological metal–organic frameworks as drug carriers

被引：0
作者：
Halil İbrahim Çetintaş [1 ]
Sema Salgın [2 ]
Uğur Salgın [2 ]
机构：
[1] Advanced Technology Research and Application Center, Sivas Cumhuriyet University, Sivas
[2] Department of Chemical Engineering, Faculty of Engineering, Sivas Cumhuriyet University, Sivas
来源：
Chemical Papers | 2025年 / 79卷 / 6期
关键词：
Cyclodextrin; Drug delivery systems; Ketoprofen; Metal–organic frameworks;
D O I：
10.1007/s11696-025-04038-z
中图分类号：
学科分类号：
摘要：
In this study, β-cyclodextrin (β-CD)-based metal–organic frameworks (MOFs) were synthesized using the vapor diffusion method, a cost-effective and straightforward approach, to evaluate their potential as drug delivery systems. Ketoprofen (KP), a poorly water-soluble nonsteroidal anti-inflammatory drug (NSAID), was used as a model drug. The effects of reaction time, temperature, ligand-to-metal salt molar ratio and cetrimonium bromide (CTAB) surfactant addition on the properties of β-CD-Bio-MOFs were systematically investigated. Optimal synthesis conditions—1 day, 30 °C, and a 1:4 β-CD:KOH molar ratio—produced quadrilateral crystals averaging 10–20 µm in size. Using KCl as the metal source yielded uniform crystals (10–40 µm), whereas NaOH and FeCl3 did not result in consistent structures. Adding CTAB as a surfactant further reduced crystal sizes to 5–20 µm. Also, KP loading experiments were conducted to optimize parameters such as temperature, agitation speed, loading time, solvent medium, and mass ratio for achieving maximum loading efficiency. The optimal conditions were determined to be 25 °C, 200 rpm, and 3 h in ethanol. Under these conditions, loading efficiencies of 13.4%, 9.6%, and 15.8% were achieved for β-CD-Bio-MOF, KCl-β-CD-Bio-MOF, and CTAB-β-CD-Bio-MOF samples, respectively, with corresponding surface areas of 11.8, 9.7, and 18.4 m2 g−1. In comparison, pure β-CD, with a specific surface area below 5 m2 g⁻1, exhibited a lower loading efficiency of 4.1%. © The Author(s), under exclusive licence to the Institute of Chemistry, Slovak Academy of Sciences 2025.
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页码：3857 / 3870
页数：13
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共 74 条
  • [1] Abuzeid H.R., El-Mahdy A.F.M., Kuo S.W., Covalent organic frameworks: design principles, synthetic strategies, and diverse applications, Giant, 6, (2021)
  • [2] Baghel D., Banjare M.K., Host-guest complexation between β-cyclodextrin and phosphonium-based ionic liquid and influence of its inclusion complex on the binding property of paracetamol drug, J Mol Liq, 389, (2023)
  • [3] Banchero M., Ronchetti S., Manna L., Characterization of ketoprofen/methyl- β -cyclodextrin complexes prepared using supercritical carbon dioxide, J Chem, 2013, (2013)
  • [4] Bauer C.A., Timofeeva T.V., Settersten T.B., Patterson B.D., Liu V.H., Simmons B.A., Allendorf M.D., Influence of connectivity and porosity on ligand-based luminescence in zinc metal−organic frameworks, J Am Chem Soc, 129, pp. 7136-7144, (2007)
  • [5] Belteky P., Ronavari A., Zakupszky D., Boka E., Igaz N., Szerencses B., Pfeiffer I., Vagvolgyi C., Kiricsi M., Konya Z., Are smaller nanoparticles always better? understanding the biological effect of size-dependent silver nanoparticle aggregation under biorelevant conditions, Int J Nanomedicine, 16, pp. 3021-3040, (2021)
  • [6] Biwer A., Antranikian G., Heinzle E., Enzymatic production of cyclodextrins, Appl Microbiol Biotechnol, 59, pp. 609-617, (2002)
  • [7] Cai H., Huang Y.L., Li D., Biological metal–organic frameworks: Structures, host–guest chemistry and bio-applications, Coord Chem Rev, 378, pp. 207-221, (2019)
  • [8] Cai G., Yan P., Zhang L., Zhou H.C., Jiang H.L., Metal-organic framework-based hierarchically porous materials: synthesis and applications, Chem Rev, 121, pp. 12278-12326, (2021)
  • [9] Carne A., Carbonell C., Imaz I., Maspoch D., Nanoscale metal–organic materials, Chem Soc Rev, 40, pp. 291-305, (2011)
  • [10] Champeau M., Thomassin J.M., Jerome C., Tassaing T., Solubility and speciation of ketoprofen and aspirin in supercritical co<sub>2</sub> by infrared spectroscopy, J Chem Eng Data, 61, pp. 968-978, (2016)
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