Alginate and chitosan-coated ferulic acid-loaded selenium nanoparticles: synthesis, characterization, and anticancer activity against MDA-MB-231 breast cancer cells

被引：0

作者：

Duygu Petunya Çetin ^{[1
]}

Mücahit Seçme ^{[2
]}

Hasan İlhan ^{[1
]}

Necdet Sağlam ^{[3
]}

机构：

[1] Ankara University,Department of Biotechnology, Institute of Biotechnology

[2] Ordu University,Department of Medical Biology, Faculty of Medicine

[3] Hacettepe University,Department of Nanotechnology and Nanomedicine, Graduate School of Science and Engineering

来源：

Medical Oncology | / 42卷 / 6期

关键词：

Breast carcinoma; Triple-negative; Breast cancer; MDA-MB-231 cells; Selenium nanoparticles; Alginate; Chitosan; Ferulic acid;

D O I：

10.1007/s12032-025-02756-8

中图分类号：

学科分类号：

摘要：

Triple-negative breast cancer (TNBC), characterized by its aggressive behavior and lack of targeted therapies, remains a major therapeutic challenge. This study presents the synthesis and evaluation of ferulic acid-loaded selenium nanoparticles (FA-SeNPs) coated with alginate (Alg@FA-SeNPs) and chitosan (CS@FA-SeNPs) as potential nanocarriers for TNBC treatment. Ferulic acid was selected for its pro-apoptotic and anti-metastatic properties, despite its limited bioavailability. Encapsulation in SeNPs enhanced its stability and delivery efficiency. Alg@FA-SeNPs exhibited greater cytotoxicity (IC50: 103.6 µg/mL) than CS@FA-SeNPs (IC50: 178 µg/mL) after 48 h. Gene expression analyses showed significant H2AX upregulation with Alg@FA-SeNPs, indicating genotoxic stress, and marked Bcl-2 downregulation with CS@FA-SeNPs, favoring apoptosis. Zeta potential measurements confirmed near-neutral surface charge for Alg@FA-SeNPs and strong positive charge for CS@FA-SeNPs, supporting good colloidal stability. These findings highlight the therapeutic promise of biopolymer-coated SeNPs, particularly alginate-coated formulations, as targeted drug delivery systems for TNBC.

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