Exosome-Mediated Cellular Communication in the Tumor Microenvironment Imparts Drug Resistance in Breast Cancer

被引:0
作者
Malla, Ramarao [1 ]
Bhamidipati, Priyamvada [1 ]
Samudrala, Anuveda Sree [1 ]
Nuthalapati, Yerusha [1 ]
Padmaraju, Vasudevaraju [1 ]
Malhotra, Aditya [2 ]
Rolig, Annah S. [2 ]
Malhotra, Sanjay V. [2 ]
机构
[1] GITAM Univ, GITAM Sch Sci, Dept Life Sci, Canc Biol Lab,Canc Biol Grp, Visakhapatnam 530045, Andhra Pradesh, India
[2] Oregon Hlth & Sci Univ, Knight Canc Inst, Ctr Expt Therapeut, Portland, OR 97201 USA
关键词
breast cancer; drug resistance; drug sensitization; exosomes; tumor microenvironment; METASTATIC NICHE FORMATION; TAMOXIFEN RESISTANCE; MECHANISMS; CELLS; CHEMORESISTANCE; FIBROBLASTS; DOXORUBICIN; SECRETION; THERAPY; HYPOXIA;
D O I
10.3390/cancers17071167
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Globally, breast cancer (BC) is the leading cause of cancer-related death for women. BC is characterized by heterogeneity, aggressive behavior, and high metastatic potential. Chemotherapy, administered as monotherapy or adjuvant therapy, remains a cornerstone of treatment; however, acquired drug resistance is a significant clinical challenge. Deciphering mechanisms of drug resistance will be central to developing more efficient treatment options and improving patient outcomes. The current review examines the multifaceted nature of exosomes in conferring drug resistance in BC through complex communication networks within the tumor microenvironment. We further explore recent advances in understanding how exosomes contribute to resistance against established chemotherapeutic agents such as tamoxifen, paclitaxel, doxorubicin, platinum-based drugs, trastuzumab, and newer immunotherapies, such as immune checkpoint inhibitors. Moreover, we discuss existing systematic approaches to investigating the exosome-drug resistance relationship in BC. Finally, we explore promising therapeutic approaches to overcome exosome-dependent drug resistance in BC, highlighting potential avenues for improved treatment efficacy. Investigating the distinct functions and cargo of exosomes offers potential for developing innovative approaches to overcoming treatment resistance.
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页数:24
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