Acyl-CoA dehydrogenase long chain acts as a tumor-suppressive factor in lung adenocarcinoma progression

被引：0
|
作者：
Wei, Tingju [1 ]
Fu, Guowei [1 ]
Zhao, Junjie [1 ]
Cao, Fengan [2 ]
Guo, Danfeng [3 ]
机构：
[1] Zhengzhou Univ, Affiliated Hosp 1, Dept Cardiac Surg, Zhengzhou, Peoples R China
[2] Zhengzhou Univ, Affiliated Hosp 1, Dept Resp Intens Care Unit, Zhengzhou, Peoples R China
[3] Zhengzhou Univ, Affiliated Hosp 1, Henan Key Lab Digest Organ Transplantat, 1 Jianshe East Rd, Zhengzhou 450052, Henan, Peoples R China
来源：
CELL ADHESION & MIGRATION | 2025年 / 19卷 / 01期
关键词：
Tumor biology; tumor invasion; long-chain acyl-CoA dehydrogenase (ACADL); epithelial-mesenchymal transition (EMT); lung cancer; CANCER; PROMOTES; CELLS;
D O I：
10.1080/19336918.2025.2495676
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
This study investigated the role of long-chain acyl-CoA dehydrogenase (ACADL) in lung adenocarcinoma (LUAD). ACADL was significantly downregulated in human LUAD tissues compared to normal lung tissues. In vitro, ectopic expression of ACADL in murine LLC cells decreased cell viability, migration, and invasion, while ACADL knockdown exhibited the opposite effect. In vivo, ACADL overexpression impeded tumor growth and metastasis. Mechanistically, ACADL hindered tumor progression by inducing cell cycle arrest, promoting apoptosis, and suppressing the epithelial-mesenchymal transition (EMT) process. These findings suggest ACADL acts as a tumor suppressor in LUAD progression.
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页数：12
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