In Silico Identification of Antimicrobial Sequences of Rainbow Trout Brain Proteins in the Context of Aquaculture Waste Recycling

被引：0

作者：

A. A. Kochneva ^{[1
]}

A. E. Kuritsin ^{[1
]}

S. A. Murzina ^{[1
]}

机构：

[1] Institute of Biology, Karelian Research Center, Russian Academy of Sciences, Petrozavodsk

来源：

Doklady Biological Sciences | 2025年 / 520卷 / 1期

关键词：

antimicrobial peptide; brain; Oncorhynchus mykiss; rainbow trout;

D O I：

10.1134/S001249662460057X

中图分类号：

学科分类号：

摘要：

Abstract: Aquaculture is one of the main sources of fish products and ensures their sustainable growth on the global scale, exceeding industrial fishing. At the same time, integrated processing of aquaculture by-products is an important environmental and industrial problem. Valuable biological components might be found in fish processing wastes left after manufacturing the target products (fillet, offal, etc.). In particular, antimicrobial peptides that exhibit broad-spectrum antimicrobial activity are expressed in fish. A first exploratory analysis of rainbow trout Oncorhynchus mykiss brain proteins was performed to identify the theoretical antimicrobial patterns. More than half of the identified proteins were predicted to have antimicrobial regions. The proteins included histones, vitellogenin, collagen, etc. The results may be of interest for designing drugs based on peptides active against various pathogens. The field is of importance in view of the increasing antibiotic resistance of pathogenic microorganisms. © Pleiades Publishing, Ltd. 2025.

引用

页码：38 / 43

页数：5

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