A 12-Week, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Lactobacillus plantarum LMT1-48 on Body Fat Loss

被引：0

作者：

Lee, Sung-Bum ^{[1
]}

Yoo, Byungwook ^{[2
]}

Baeg, Chaemin ^{[3
]}

Yun, Jiae ^{[4
]}

Ryu, Dong-wook ^{[4
]}

Kim, Gyungcheon ^{[5
,6
]}

Kim, Seongok ^{[5
,6
]}

Shin, Hakdong ^{[5
,6
]}

Lee, Ju Hee ^{[7
,8
]}

机构：

[1] Soonchunhyang Univ, Dept Family Med, Bucheon Hosp, Bucheon 22972, South Korea

[2] Soonchunhyang Univ Seoul Hosp, Dept Family Med, Seoul 04401, South Korea

[3] Global Med Res Ctr, Seoul 06526, South Korea

[4] Medytox Inc, Gwanggyo R&D Ctr, Suwon 16506, South Korea

[5] Sejong Univ, Dept Food Sci & Biotechnol, Coll Life Sci, Seoul 05006, South Korea

[6] Sejong Univ, Coll Life Sci, Carbohydrate Bioprod Res Ctr, Seoul 05006, South Korea

[7] Yonsei Univ, Coll Med, Dept Dermatol, Seoul 03722, South Korea

[8] Yonsei Univ, Cutaneous Biol Res Inst, Coll Med, Seoul 03722, South Korea

来源：

NUTRIENTS | 2025年 / 17卷 / 07期

关键词：

Lactobacillus plantarum; probiotics; obesity; body fat loss; OBESITY;

D O I：

10.3390/nu17071191

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Objectives: This study aims to evaluate the efficacy and safety of probiotics for body fat reduction in obese individuals. Methods: A total of 106 participants with a body mass index between 25 and 30 kg/m2 were randomly assigned to either the experimental group treating with Lactobacillus plantarum LMT1-48 or the placebo group in the placebo-controlled clinical trial. Body composition was assessed by dual-energy X-ray absorptiometry and computed tomography. Fecal samples between the groups were contrasted via DNA sequencing for evaluation of the microbiota and its diversity. Results: After 12 weeks of follow-up period, the body fat mass decreased significantly, from 30.0 +/- 4.4 to 28.3 +/- 4.1 kg in the experimental group (p = 0.009). The percentage of body fat in the two groups showed a similar trend (p = 0.004). Conclusions: LMT1-48 also positively influenced the microbial taxa linked to obesity analyzed by gut microbiome sequencing. LMT1-48 is a safe and collaborative agent to reduce obesity.

引用

页数：15

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