Predictive Factors of ART Follow-Up Loss in HIV Patients (2018-2022): A Retrospective Cohort Study

被引:0
作者
Li, Mengjie [1 ]
Chen, Hang [2 ]
Xiao, Ticheng [1 ,2 ]
Ma, Ji [1 ]
Ding, Mingzhe [1 ]
Huang, Fuli [3 ]
Chen, Yanhua [3 ,4 ]
Chen, Run [1 ]
Li, Ailing [1 ]
Fan, Song [1 ]
机构
[1] Southwest Med Univ, Sch Publ Hlth, Luzhou 646000, Sichuan, Peoples R China
[2] Luzhou Ctr Dis Control & Prevent, Luzhou, Peoples R China
[3] Southwest Med Univ, Affiliated Hosp, Luzhou, Peoples R China
[4] Southwest Med Univ, Sch Nursing, Luzhou, Peoples R China
关键词
HIV/AIDS; Antiretroviral Therapy; Loss to Follow-Up; Cox Risk Regression; Retrospective Cohort Study; ANTIRETROVIRAL THERAPY; INITIATION; MORTALITY; HIV/AIDS; OUTCOMES;
D O I
暂无
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Loss to follow-up (LTFU) in antiretroviral therapy (ART) poses significant challenges in the management of HIV/AIDS. This study aims to identify socio-demographic and clinical factors influencing LTFU among patients undergoing ART in Luzhou, China, and to develop a predictive model for LTFU using Cox risk regression analysis. In this retrospective cohort study, data from 8,770 patients diagnosed with HIV infection between January 1, 2018 and December 31, 2022 who were enrolled in the national free ART program were analyzed. The primary outcome was the first occurrence of LTFU. Cox proportional risk regression analyses were conducted to identify predictors of LTFU. The study population had a median age of 64.25 years, and 73.2% were male. The overall LTFU rate was 4.14 per 100 person-years. Factors associated with a decreased likelihood of LTFU included female gender, homosexual transmission, absence of HIV-related diseases, negative HBV surface antigen, higher final CD4 count, and an increase in CD4 count from baseline. In contrast, older age, longer time from diagnosis to ART initiation, higher baseline viral load, missed medication doses, and the development of medication side-effects were associated with an increased risk of LTFU. Our prediction model identifying the risk of loss to follow-up demonstrated good predictive performance with a C-index of 0.721. The study highlights the importance of considering a range of socio-demographic and clinical factors in managing LTFU among people living with HIV (PLHIV) on ART. Our prediction model can be a valuable tool for healthcare providers to identify patients at high risk of LTFU, facilitating targeted interventions to improve treatment adherence and outcomes.
引用
收藏
页码:1205 / 1215
页数:11
相关论文
共 43 条
  • [1] Developing and implementing an HIV/AIDS educational curriculum for older adults
    Altschuler, J
    Katz, AD
    Tynan, M
    [J]. GERONTOLOGIST, 2004, 44 (01) : 121 - 126
  • [2] Factors associated with attrition, mortality, and loss to follow up after antiretroviral therapy initiation: data from an HIV cohort study in India
    Alvarez-Uria, Gerardo
    Naik, Praveen K.
    Pakam, Raghavakalyan
    Midde, Manoranjan
    [J]. GLOBAL HEALTH ACTION, 2013, 6 : 1 - 8
  • [3] [Anonymous], 2006, ANTIRETROVIRAL THERA
  • [4] [Anonymous], HIV among people aged 50 and older
  • [5] Antiretroviral Therapy for HIV Infection in Adults and Adolescents, 2010, RECOMMENDATIONS PUBL, P23741771
  • [6] Risk factors for loss to follow-up, transfer or death among people living with HIV on their first antiretroviral therapy regimen in Mali
    Balde, A.
    Lievre, L.
    Maiga, A. I.
    Diallo, F.
    Maiga, I. A.
    Costagliola, D.
    Abgrall, S.
    [J]. HIV MEDICINE, 2019, 20 (01) : 47 - 53
  • [7] Status of HIV-infected patients classified as lost to follow up from a large antiretroviral program in southwest Nigeria
    Balogun, Mobolanle
    Meloni, Seema Thakore
    Igwilo, Ugonnaya Ugochinyere
    Roberts, Alero
    Okafor, Ifeoma
    Sekoni, Adekemi
    Ogunsola, Folasade
    Kanki, Phyllis J.
    Akanmu, Sulaimon
    [J]. PLOS ONE, 2019, 14 (07):
  • [8] Predictors of Loss to follow-up in Patients Living with HIV/AIDS after Initiation of Antiretroviral Therapy
    Berheto, Tezera Moshago
    Haile, Demissew Berihun
    Mohammed, Salahuddin
    [J]. NORTH AMERICAN JOURNAL OF MEDICAL SCIENCES, 2014, 6 (09) : 453 - 459
  • [9] China Center for Disease Control and Prevention, 2023, NATL MANUAL FREE ANT
  • [10] Loss to Follow-Up in a Cohort of HIV-Infected Patients in a Regional Referral Outpatient Clinic in Brazil
    de Almeida, Meire Cavalieri
    Pedroso, Nayara de Jesus
    Lina van Keulen, Maria do Socorro
    Ortega Jacome, Guillermo Patricio
    Fernandes, Guilherme Cortes
    Yokoo, Edna Massae
    Tuboi, Suely Hiromi
    [J]. AIDS AND BEHAVIOR, 2014, 18 (12) : 2387 - 2396