Mesonephric-like adenocarcinoma of the female genital tract: Pathologic diagnosis, clinical outcomes, and novel therapeutics

被引：0

作者：

Ring, Kari L. ^{[1
]}

Mills, Anne M. ^{[2
]}

Howitt, Brooke E. ^{[3
]}

Grisham, Rachel N. ^{[4
,5
]}

Euscher, Elizabeth D. ^{[6
]}

Kim, Hyun-Soo ^{[7
]}

Klopp, Ann H. ^{[8
]}

Kolin, David L. ^{[9
]}

McCluggage, W. Glenn ^{[10
]}

Mirkovic, Jelena ^{[11
]}

Park, Kay J. ^{[12
]}

Aoun, Eliane ^{[13
]}

Awujo, Chika ^{[13
]}

So, Ji ^{[13
]}

Mo, Samuel C. ^{[13
]}

Ferri-Borgogno, Sammy ^{[13
]}

Hong, David S. ^{[14
]}

Hoang, Lien ^{[15
]}

Jazaeri, Amir A. ^{[13
]}

How, Jeffrey A. ^{[13
]}

Lu, Karen H. ^{[16
]}

机构：

[1] Univ Virginia Hlth Syst, Dept Obstet & Gynecol, Charlottesville, VA USA

[2] Univ Virginia Hlth Syst, Dept Pathol, Charlottesville, VA USA

[3] Stanford Univ, Sch Med, Dept Pathol, Stanford, CA USA

[4] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY USA

[5] Weill Cornell Med Coll, New York, NY USA

[6] Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX USA

[7] Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Pathol & Translat Genom, Seoul, South Korea

[8] Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX USA

[9] Brigham & Womens Hosp, Dept Pathol, Boston, MA USA

[10] Belfast Hlth & Social Care Trust, Dept Pathol, Belfast, North Ireland

[11] Sunnybrook Hlth Sci Ctr, Dept Pathol, Toronto, ON, Canada

[12] Mem Sloan Kettering Canc Ctr, Dept Pathol & Lab Med, New York, NY USA

[13] Univ Texas MD Anderson Canc Ctr, Dept Gynecol Oncol & Reprod Med, Houston, TX USA

[14] Univ Texas MD Anderson Canc Ctr, Dept Med Oncol, Houston, TX USA

[15] Vancouver Gen Hosp, Dept Pathol, Vancouver, BC, Canada

[16] H Lee Moffitt Canc Ctr & Res Inst, Dept Gynecol Oncol, Tampa, FL USA

来源：

GYNECOLOGIC ONCOLOGY | 2025年 / 197卷

基金：

美国国家卫生研究院; 英国惠康基金;

关键词：

Mesonephric-like adenocarcinoma; Endometrial cancer; Ovarian cancer; Novel therapeutics; UTERINE CORPUS; PROGNOSTIC CHARACTERISTICS; MOLECULAR CHARACTERIZATION; PHASE-I; CARCINOSARCOMA; CARCINOMA; CERVIX; TUMORS; NEOPLASMS; PAX8;

D O I：

10.1016/j.ygyno.2025.04.583

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In 2016, McCluggage and colleagues first defined mesonephric-like adenocarcinoma (MLA) of the uterus and extra-uterine sites. Following this initial description, the World Health Organization officially recognized MLA as a type of uterine and ovarian carcinoma and subsequent studies have further refined the morphologic definition, immunohistochemical profile, molecular underpinnings, and clinical behavior in this rare entity. A consortium of pathologists, gynecologic oncologists, medical oncologists, radiation oncologists, as well as basic science collaborators with expertise in MLA was convened to develop consensus regarding the pathologic diagnosis, and to identify unanswered questions and priority areas for research. Here, we review the current understanding of MLA from a pathologic, molecular, and clinical standpoint. (c) 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

引用

页码：57 / 65

页数：9

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