Advances and challenges in the application of donor-derived cell-free DNA for diagnosis and treatment in liver transplantation: a narrative review

被引：0

作者：

Zhong, Yiwu ^{[1
]}

Hu, Xu ^{[1
]}

Li, Xiaoping ^{[2
]}

Qiao, Yinbiao ^{[3
]}

Li, Haoyu ^{[3
]}

Zhou, Shijie ^{[3
]}

Zheng, Shusen ^{[3
,4
]}

Li, Jianhui ^{[2
,3
,4
,5
]}

机构：

[1] Zhejiang Chinese Med Univ, Hangzhou 310053, Peoples R China

[2] Zhejiang Shuren Univ, Shulan Int Med Coll, Key Lab Artificial Organs & Computat Med Zhejiang, Hangzhou, Zhejiang, Peoples R China

[3] NHC Key Lab Combined Multiorgan Transplantat, Hangzhou 310003, Peoples R China

[4] Zhejiang Shuren Univ, Shulan Int Med Coll, Shulan Hangzhou Hosp, Key Lab Artificial Organs & Computat Med Zhejiang, Hangzhou 310022, Peoples R China

[5] Organ Repair & Regenerat Med Inst Hangzhou, Hangzhou 310003, Peoples R China

来源：

BMC SURGERY | 2025年 / 25卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Donor-derived cell-free DNA; Biomarkers; Liver transplantation; Non-invasive Monitoring; Transplant monitoring; ORGAN INTEGRITY BIOMARKER; UNIVERSAL BIOMARKER; ALLOGRAFT-REJECTION; PLASMA DNA; KIDNEY; MARKER; RISK; RECIPIENTS; QUANTIFICATION; MORTALITY;

D O I：

10.1186/s12893-025-02911-y

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

In the field of liver disease treatment, liver transplantation (LT) has become an effective option for end-stage liver disease. However, issues such as immune rejection and graft damage remain important factors influencing the success rate of liver transplantation and patients' quality of life. In recent years, with the advancement of genetic testing technologies, the study and application of donor-derived cell-free DNA (dd-cfDNA) in LT diagnosis and treatment have gradually gained attention. This review explores the research advancements in dd-cfDNA within liver transplant management, evaluating its potential applications throughout the liver transplantation process, while exploring the challenges faced by current studies and outlining future research directions. As a strategic tool for postoperative monitoring in LT, dd-cfDNA shows promising potential in areas such as immune rejection, graft damage, immunosuppressant adjustment, complication monitoring, and personalized treatment, and is poised to become a reliable biomarker in LT management.

引用

页数：11

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