Mesenchymal stem cells in hematology: Therapeutic initiatives and future directions

被引：0
作者：
Smallbone, Portia [1 ]
Kebriaei, Partow [1 ]
Mendt, Mayela [1 ]
Shpall, Elizabeth J. [1 ]
Olson, Amanda L. [1 ]
Fingrut, Warren B. [1 ]
机构：
[1] Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat & Cellular Therapy, Houston, TX 77030 USA
来源：
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY | 2025年 / 38卷 / 01期
关键词：
Mesenchymal stem cells; Graft-versus-host disease; Cell therapy; Hematopoietic stem cell transplantation; Immune thrombocytopenic purpura; VERSUS-HOST-DISEASE; SEVERE APLASTIC-ANEMIA; UMBILICAL-CORD BLOOD; PHASE-III TRIAL; STROMAL CELLS; BONE-MARROW; IMMUNE THROMBOCYTOPENIA; REMESTEMCEL-L; COTRANSPLANTATION; TRANSPLANTATION;
D O I：
10.1016/j.beha.2025.101613
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In recent years, the landscape of hematology has undergone rapid transformation, driven by innovative therapeutic strategies harnessing the properties of novel cellular therapies. Mesenchymal stem cells (MSCs) represent one of these promising therapies, with potential applications across a range of hematologic conditions. These cells are notable for their immunomodulatory properties, key role in supporting the hematopoietic micro-environment and capacity for multidirectional differentiation. This review will focus on the biologic mechanisms underlying MSC therapeutic use, current avenues of clinical investigation, and potential challenges and future directions for MSC derived therapies.
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页数：14
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共 101 条
  • [1] Glioblastoma Therapy with Cytotoxic Mesenchymal Stromal Cells Optimized by Bioluminescence Imaging of Tumor and Therapeutic Cell Response
    Alieva, Maria
    Bago, Juli R.
    Aguilar, Elisabet
    Soler-Botija, Carolina
    Vila, Olaia F.
    Molet, Joan
    Gambhir, Sanjiv S.
    Rubio, Nuria
    Blanco, Jeronimo
    [J]. PLOS ONE, 2012, 7 (04):
  • [2] [Anonymous], FDA Approves First Mesenchymal Stromal Cell Therapy to Treat Steroid-refractory Acute Graft-versus-host Disease
  • [3] How I treat acquired aplastic anemia
    Bacigalupo, Andrea
    [J]. BLOOD, 2017, 129 (11) : 1428 - 1436
  • [4] Cotransplantation of ex vivo-expanded mesenchymal stem cells accelerates lymphocyte recovery and may reduce the risk of graft failure in haploidentical hematopoietic stem-cell transplantation
    Ball, Lynne M.
    Bernardo, Maria Ester
    Roelofs, Helene
    Lankester, Arjan
    Cometa, Angela
    Egeler, R. Maarten
    Locatelli, Franco
    Fibbe, Willem E.
    [J]. BLOOD, 2007, 110 (07) : 2764 - 2767
  • [5] Systemic delivery of bone marrow-derived mesenchymal stem cells to the infarcted myocardium - Feasibility, cell migration, and body distribution
    Barbash, IM
    Chouraqui, P
    Baron, J
    Feinberg, MS
    Etzion, S
    Tessone, A
    Miller, L
    Guetta, E
    Zipori, D
    Kedes, LH
    Kloner, RA
    Leor, J
    [J]. CIRCULATION, 2003, 108 (07) : 863 - 868
  • [6] Cotransplantation of Mesenchymal Stem Cells Might Prevent Death from Graft-versus-Host Disease (GVHD) without Abrogating Graft-versus-Tumor Effects after HLA-Mismatched Allogeneic Transplantation following Nonmyeloablative Conditioning
    Baron, Frederic
    Lechanteur, Chantal
    Willems, Evelyne
    Bruck, France
    Baudoux, Etienne
    Seidel, Laurence
    Vanbellinghen, Jean-Francois
    Hafraoui, Kaoutar
    Lejeune, Marie
    Gothot, Andre
    Fillet, Georges
    Beguin, Yves
    [J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2010, 16 (06) : 838 - 847
  • [7] VEGF expression by mesenchymal stem cells contributes to angiogenesis in pancreatic carcinoma
    Beckermann, B. M.
    Kallifatidis, G.
    Groth, A.
    Frommhold, D.
    Apel, A.
    Mattern, J.
    Salnikov, A. V.
    Moldenhauer, G.
    Wagner, W.
    Diehlmann, A.
    Saffrich, R.
    Schubert, M.
    Ho, A. D.
    Giese, N.
    Buechler, M. W.
    Friess, H.
    Buechler, P.
    Herr, I.
    [J]. BRITISH JOURNAL OF CANCER, 2008, 99 (04) : 622 - 631
  • [8] Mesenchymal Stem Cell-Derived Microvesicles Protect Against Acute Tubular Injury
    Bruno, Stefania
    Grange, Cristina
    Deregibus, Maria Chiara
    Calogero, Raffaele A.
    Saviozzi, Silvia
    Collino, Federica
    Morando, Laura
    Busca, Alessandro
    Falda, Michele
    Bussolati, Benedetta
    Tetta, Ciro
    Camussi, Giovanni
    [J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2009, 20 (05): : 1053 - 1067
  • [9] Why are MSCs therapeutic? New data: new insight
    Caplan, Al
    [J]. JOURNAL OF PATHOLOGY, 2009, 217 (02) : 318 - 324
  • [10] The efficacy of mesenchymal stem cells in bronchiolitis obliterans syndrome after allogeneic HSCT: A multicenter prospective cohort study
    Chen, Shan
    Zhao, Ke
    Lin, Ren
    Wang, Shunqing
    Fan, Zhiping
    Huang, Fen
    Chen, Xiaoyong
    Nie, Danian
    Du, Xin
    Guo, Ziwen
    Lin, Dongjun
    Xuan, Li
    Xu, Na
    Sun, Jing
    Xiang, Andy Peng
    Liu, Qifa
    [J]. EBIOMEDICINE, 2019, 49 : 213 - 222
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