TBAI-mediated electrochemical oxidative synthesis of quinazolin-4(3H)-ones from 2-aminobenzamides and isothiocyanates

被引：0

作者：

Huang, Jingbin ^{[1
]}

Liu, Yafeng ^{[3
]}

Huang, Yu ^{[1
]}

Wu, Xiuli ^{[1
]}

Lan, Xiao-Bing ^{[1
]}

Yu, Jian-Qiang ^{[1
]}

Li, Wenxue ^{[1
]}

Zheng, Ping ^{[1
]}

Zhang, Jian ^{[1
,2
]}

An, Zhenyu ^{[1
]}

机构：

[1] Ningxia Med Univ, Sch Pharm, Key Lab Protect Dev & Utilizat Med Resources Liupa, Minist Educ,Peptide & Prot Drug Res Ctr, Yinchuan 750004, Peoples R China

[2] Shanghai Jiao Tong Univ, Med Chem & Bioinformat Ctr, Sch Med, Shanghai 200025, Peoples R China

[3] North MinzuUniv, Sch Chem & Chem Engn, Yinchuan 750000, Ningxia, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2025年

基金：

中国国家自然科学基金;

关键词：

EFFICIENT SYNTHESIS; QUINAZOLINONES; LIBRARY;

D O I：

10.1039/d5ob00410a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical protocol has been established to access 2-aminoquinazolin-4(3H)-one derivatives through the electrochemical desulfurative cyclization of 2-aminobenzamides and isothiocyanates. The protocol allows for the formation of C-N bonds under mild conditions without metal catalysts or external oxidants. The practicability of this strategy is demonstrated by its broad substrate scope, good functional group compatibility, and scale-up synthesis.

引用

页数：6

共 48 条

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