Impact of margin distance on recurrence and survival following breast-conserving surgery after neoadjuvant systemic therapy

被引：0

作者：

Pop, C. Florin ^{[1
]}

Ortega, Clemence ^{[1
]}

Lecomte, Mathilde ^{[1
]}

Kristanto, Paulus ^{[2
,3
]}

Khaled, Chirine ^{[4
]}

De Neubourg, Filip ^{[1
]}

Desmet, Antoine ^{[5
]}

De Azambuja, Evandro ^{[6
]}

Larsimont, Denis ^{[4
]}

Veys, Isabelle ^{[1
]}

机构：

[1] Univ Libre Bruxelles, Brussels Univ Hosp HUB, Inst Jules Bordet, Dept Surg Oncol,Breast Clin, Brussels, Belgium

[2] Univ Libre Bruxelles, Brussels Univ Hosp HUB, Inst Jules Bordet, Data Ctr, Brussels, Belgium

[3] Univ Libre Bruxelles, Brussels Univ Hosp HUB, Inst Jules Bordet, Stat Dept, Brussels, Belgium

[4] Univ Libre Bruxelles, Brussels Univ Hosp HUB, Inst Jules Bordet, Dept Pathol, Brussels, Belgium

[5] Univ Libre Bruxelles, Brussels Univ Hosp HUB, Inst Jules Bordet, Dept Radiat Therapy, Brussels, Belgium

[6] Univ Libre Bruxelles, Brussels Univ Hosp HUB, Inst Jules Bordet, Dept Med Oncol, Brussels, Belgium

来源：

NPJ BREAST CANCER | 2025年 / 11卷 / 01期

关键词：

PATHOLOGICAL COMPLETE RESPONSE; LOCOREGIONAL RECURRENCE; CANCER; CHEMOTHERAPY; CONSERVATION; MRI;

D O I：

10.1038/s41523-025-00756-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Current evidence does not support the application of "no-ink-on-tumor" negative margins following breast-conserving surgery (BCS) in breast cancer (BC) patients who have received neoadjuvant systemic treatment (NST). We compared loco-regional free survival (LRFS), disease-free survival (DFS), and overall survival (OS) based on different tumor margin distance thresholds in a cohort of 235 BC patients treated with NST and subsequent BCS between 01/2015 and 12/2019. The 5-year LRFS was 81.6% in patients with "no-ink-on-tumour", margins and 71.0% in those with positive margins (p = 0.584). Margins >1 mm were associated with superior outcomes, with a 5-year LRFS of 84.0% compared to 69.3% in patients with margins <= 1 mm (p = 0.005). Additionally, margins >1 mm were significantly correlated with longer DFS (p = 0.028) and OS (p = 0.001). These findings suggest that a surgical margin distance >1 mm provides the best LRFS, DFS, and OS outcomes for this group of BC patients.

引用

页数：8

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