Mechanics and disease of heart cells/cardiomyocytes explored through atomic force microscopy: present and future

被引：1
作者：
Villarreal, Lihuen [2 ]
Fontes-Silva, Mateo [1 ]
Mendaro, Laura [1 ]
Romanelli, Gerardo [1 ,3 ]
Benech, Juan C. [1 ,2 ]
机构：
[1] Inst Invest Biol Clemente Estable IIBCE, Lab Senalizac Celular & Nanobiol, Ave Italia 3318, Montevideo 11600, Uruguay
[2] Inst Invest Biol Clemente Estable IIBCE, Plataforma Microscopia Fuerza Atom, Ave Italia 3318, Montevideo 11600, Uruguay
[3] IIBCE, Dept Neurobiol & Neuropatol, Ave Italia 3318, Montevideo 11600, Uruguay
来源：
BIOPHYSICAL REVIEWS | 2025年 / 17卷 / 02期
关键词：
Nanomechanics; Cardiomyocytes; Diabetes mellitus; Cardiomyopathy; Atomic force microscopy; INCREASED AORTIC STIFFNESS; SINGLE CARDIOMYOCYTES; INCREASES STIFFNESS; CELL MECHANICS; ELASTICITY; VINCULIN; SAMPLES; SYSTEM;
D O I：
10.1007/s12551-025-01307-9
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
According to the World Health Organization (WHO), cardiovascular diseases are the leading cause of death worldwide. Several diseases have been linked to changes in cellular mechanical properties, including those affecting the heart. Atomic force microscopy (AFM) has proven to be one of the most effective techniques for precisely determining the topography and mechanical properties of adherent living cells. In this review, we provide a short chronological overview of key studies conducted using AFM on cardiac cells or cardiomyocytes with clinical and medical significance. These studies have contributed and continue to enhance our understanding of the pathological processes affecting the heart and clarify the role of cell mechanics in cardiac and cardiovascular diseases.
引用
收藏
页码：347 / 358
页数：12
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