1H, 13C and 15N backbone resonance assignment of the catalytic domain of human PTPN22

被引：0

作者：

Martin, Bryan T. ^{[1
]}

Clarkson, Michael W. ^{[1
]}

Wu, Ping ^{[1
]}

Di Lello, Paola ^{[1
]}

机构：

[1] Genentech Inc, Dept Struct Biol Prot Sci, South San Francisco, CA 94080 USA

来源：

BIOMOLECULAR NMR ASSIGNMENTS | 2025年

关键词：

PTPN22; Phosphatases; NMR assignment; Drug discovery; NMR spectroscopy; LYMPHOID TYROSINE PHOSPHATASE; LYP; IDENTIFICATION; INHIBITOR;

D O I：

10.1007/s12104-025-10233-6

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Protein Tyrosine Phosphatase Non-receptor type 22 (PTPN22) is a tyrosine-phosphatase that plays a major role in inhibiting T-cell activation in immune cells. Recent studies have revealed that downregulation of PTPN22 triggers T-cell activation and enhances antitumor immune response, thereby identifying PTPN22 as a potential pharmacological target in cancer-immunology.Here we report the 1H, 15N and 13C backbone resonance assignment for the 35.6 kDa catalytic domain of human PTPN22. This assignment will provide an essential experimental tool to identify and characterize potential PTPN22 inhibitors.

引用

页码：175 / 181

页数：7

共 22 条

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