Repurposing of epalrestat for neuroprotection in parkinson’s disease via activation of the KEAP1/Nrf2 pathway

被引：0
|
作者：
Huafang Jia [1 ]
Mengru Liu [1 ]
Hong Jiang [1 ]
Zhen Qiao [2 ]
Kaiyue Ren [2 ]
Xixun Du [1 ]
Xi Chen [1 ]
Qian Jiao [1 ]
Fengyuan Che [1 ]
机构：
[1] Qingdao Medical College,Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines, Physiology, School of Basic Medicine
[2] Qingdao University,Shandong Key Laboratory of Neurorehabilitation, School of Life Sciences and Health
[3] University of Health and Rehabilitation Sciences,Shandong Provincial Clinical Research Center for Geriatric Diseases; Key Laboratory of Neurophysiology, Health Commission of Shandong Province; Linyi Key Laboratory of Neurophysiology, Department of Neurolog
[4] Linyi People’s Hospital,undefined
来源：
Journal of Neuroinflammation | / 22卷 / 1期
关键词：
Epalrestat; Parkinson’s disease; KEAP1; Nrf2; Oxidative stress; Mitochondrial dysfunction;
D O I：
10.1186/s12974-025-03455-x
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [21] Role of the Keap1/Nrf2 pathway in neurodegenerative diseases
    Yamazaki, Hiromi
    Tanji, Kunikazu
    Wakabayashi, Koichi
    Matsuura, Shin
    Itoh, Ken
    PATHOLOGY INTERNATIONAL, 2015, 65 (05) : 210 - 219
  • [22] Activation of the Keap1/Nrf2 stress response pathway in autophagic vacuolar myopathies
    Duleh, Steve
    Wang, Xianhong
    Komirenko, Allison
    Margeta, Marta
    ACTA NEUROPATHOLOGICA COMMUNICATIONS, 2016, 4 : 115
  • [23] Activation of the Keap1/Nrf2 stress response pathway in autophagic vacuolar myopathies
    Steve Duleh
    Xianhong Wang
    Allison Komirenko
    Marta Margeta
    Acta Neuropathologica Communications, 4
  • [24] Activation of Nrf2 Translation by a Keap1 Independent Mechanism
    Perez-Leal, Oscar
    Barrero, Carlos A.
    Merali, Salim
    FREE RADICAL BIOLOGY AND MEDICINE, 2016, 100 : S108 - S108
  • [25] Tethering of Nrf2 to Keap1 prevents Nrf2 degradation by the ubiquitin proteasome pathway
    Sekhar, K
    Yan, X
    Freeman, M
    FREE RADICAL BIOLOGY AND MEDICINE, 2002, 33 : S350 - S351
  • [26] GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway
    Jingjing Li
    Qiujie Wang
    Yi Yang
    Chong Lei
    Fan Yang
    Li Liang
    Chang Chen
    Jie Xia
    Kai Wang
    Ni Tang
    Journal of Experimental & Clinical Cancer Research, 38
  • [27] GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway
    Li, Jingjing
    Wang, Qiujie
    Yang, Yi
    Lei, Chong
    Yang, Fan
    Liang, Li
    Chen, Chang
    Xia, Jie
    Wang, Kai
    Tang, Ni
    JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2019, 38 (01) : 438
  • [28] Nrf2 activation through the inhibition of Keap1–Nrf2 protein–protein interaction
    Sumi Lee
    Longqin Hu
    Medicinal Chemistry Research, 2020, 29 : 846 - 867
  • [29] Keap1 Eye on Nrf2• Targets for Disease Prevention
    Kensler, T.
    ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 2010, 51 (07) : 685 - 685
  • [30] Systemic activation of Nrf2 pathway in Parkinson's disease
    Petrillo, Sara
    Schirinzi, Tommaso
    Di Lazzaro, Giulia
    D'Amico, Jessica
    Colona, Vito L.
    Bertini, Enrico
    Pierantozzi, Mariangela
    Mari, Luisa
    Mercuri, Nicola B.
    Piemonte, Fiorella
    Pisani, Antonio
    MOVEMENT DISORDERS, 2020, 35 (01) : 180 - 184
12345