Repurposing of epalrestat for neuroprotection in parkinson’s disease via activation of the KEAP1/Nrf2 pathway

被引：0
|
作者：
Huafang Jia [1 ]
Mengru Liu [1 ]
Hong Jiang [1 ]
Zhen Qiao [2 ]
Kaiyue Ren [2 ]
Xixun Du [1 ]
Xi Chen [1 ]
Qian Jiao [1 ]
Fengyuan Che [1 ]
机构：
[1] Qingdao Medical College,Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines, Physiology, School of Basic Medicine
[2] Qingdao University,Shandong Key Laboratory of Neurorehabilitation, School of Life Sciences and Health
[3] University of Health and Rehabilitation Sciences,Shandong Provincial Clinical Research Center for Geriatric Diseases; Key Laboratory of Neurophysiology, Health Commission of Shandong Province; Linyi Key Laboratory of Neurophysiology, Department of Neurolog
[4] Linyi People’s Hospital,undefined
来源：
Journal of Neuroinflammation | / 22卷 / 1期
关键词：
Epalrestat; Parkinson’s disease; KEAP1; Nrf2; Oxidative stress; Mitochondrial dysfunction;
D O I：
10.1186/s12974-025-03455-x
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [1] Activation of the Keap1/Nrf2 pathway for neuroprotection by electrophillic phase II inducers
    Satoh, T
    Okamoto, SI
    Cui, J
    Watanabe, Y
    Furuta, K
    Suzuki, M
    Tohyama, K
    Lipton, SA
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (03) : 768 - 773
  • [2] Identification and optimization of piperine analogues as neuroprotective agents for the treatment of Parkinson's disease via the activation of Nrf2/keap1 pathway
    Wang, Lun
    Cai, Xiaoying
    Shi, Mingsong
    Xue, Linlin
    Kuang, Shuang
    Xu, Ruiling
    Qi, Wenyan
    Li, Yan
    Ma, Xu
    Zhang, Ruijia
    Hong, Feng
    Ye, Haoyu
    Chen, Lijuan
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 199
  • [3] Formononetin Exerts Neuroprotection in Parkinson's Disease via the Activation of the Nrf2 Signaling Pathway
    Wang, Xiaotong
    Kang, Nianxin
    Liu, Ying
    Xu, Guojie
    MOLECULES, 2024, 29 (22):
  • [4] Keap1/Nrf2 Signaling Pathway
    Sykiotis, Gerasimos P.
    ANTIOXIDANTS, 2021, 10 (06)
  • [5] The principal molecular mechanisms behind the activation of Keap1/Nrf2/ARE pathway leading to neuroprotective action in Parkinson's disease
    Chakkittukandiyil, Amritha
    Sajini, Deepak Vasudevan
    Karuppaiah, Arjunan
    Selvaraj, Divakar
    NEUROCHEMISTRY INTERNATIONAL, 2022, 156
  • [6] Loss-of-function mutations in KEAP1 drive lung cancer progression via KEAP1/NRF2 pathway activation
    Meiling Gong
    Yan Li
    Xiaoping Ye
    Linlin Zhang
    Zhifang Wang
    Xiaowen Xu
    Yejing Shen
    Cuixia Zheng
    Cell Communication and Signaling, 18
  • [7] Loss-of-function mutations in KEAP1 drive lung cancer progression via KEAP1/NRF2 pathway activation
    Gong, Meiling
    Li, Yan
    Ye, Xiaoping
    Zhang, Linlin
    Wang, Zhifang
    Xu, Xiaowen
    Shen, Yejing
    Zheng, Cuixia
    CELL COMMUNICATION AND SIGNALING, 2020, 18 (01)
  • [8] The cytoprotective role of the Keap1–Nrf2 pathway
    Liam Baird
    Albena T. Dinkova-Kostova
    Archives of Toxicology, 2011, 85 : 241 - 272
  • [9] The KEAP1/NRF2 Signaling Pathway in Keratinization
    Ishitsuka, Yosuke
    Ogawa, Tatsuya
    Roop, Dennis
    ANTIOXIDANTS, 2020, 9 (08) : 1 - 24
  • [10] TARGETING THE Keap1/Nrf2 PATHWAY FOR CHEMOPROTECTION
    Dinkova-Kostova, Albena
    FREE RADICAL BIOLOGY AND MEDICINE, 2014, 76 : S5 - S5
12345