Overview of the histopathological and immunohistochemical characteristics of neuroendocrine neoplasms

被引：0

作者：

Sonia L. El-Sharkawy ^{[1
]}

Manal A. Badawi ^{[1
]}

Wafaa E. Abdelaal ^{[1
]}

Naglaa F. Abbas ^{[1
]}

机构：

[1] Medical Research and Clinical Studies Institute,Pathology Department

[2] National Research Centre,undefined

来源：

Bulletin of the National Research Centre | / 49卷 / 1期

关键词：

Neuroendocrine neoplasms; Histopathology; Immunohistochemistry;

D O I：

10.1186/s42269-025-01320-8

中图分类号：

学科分类号：

摘要：

Neuroendocrine neoplasms [NENs] are a group of rare tumors that evolve from neuroendocrine cells and show different morphological patterns and clinical and biological characteristics. These tumors are diverse in terms of sites of origin, functional status, degree of aggressiveness, and patients outcome. Although they share certain histopathological features regardless of their sites, they have been studied in an organ–specific manner and their grading remain site specific. In this review, we provide on the contemporary understanding of neuroendocrine tumors, pathological and immunohistochemical characteristics that help in tumor diagnosis paving the way for the development of new diagnostic techniques. Additionally molecular alterations, genetic mut ations and the biomarkers used to detect tumors at an earlier stage were summarized. Many researches evaluating prognostic markers and allowing for personalized treatment options are recommended.

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