Molecular Signatures of Aeroallergen Sensitization in Pediatric Populations: A Comparative Study Across Spanish Cities

被引：0

作者：

Martinez-Canavate, Ana ^{[1
]}

Mesa-Del-Castillo, Maria ^{[2
]}

Carballada, Francisco ^{[3
]}

Rivas-Juesas, Cristina ^{[4
]}

Porto, Jose Angel ^{[5
]}

Blasco, Cristina ^{[6
]}

Alvaro-Lozano, Montserrat ^{[7
]}

Lozano, Jaime ^{[7
]}

Manrique, Julian Andres ^{[7
]}

Martinez, Maria Jose ^{[8
]}

Galan, Tania ^{[8
]}

Domingo, Gema ^{[9
]}

Marin, Laura ^{[1
]}

Vega, Pilar ^{[2
]}

Lopez-Rodriguez, Raquel ^{[3
]}

Galan, Praxedes Solano ^{[4
]}

Aliaga, Yolanda ^{[6
]}

Pineda, Fernando ^{[8
]}

Tortajada-Girbes, Miguel ^{[9
]}

机构：

[1] Hosp Univ Virgen Nieves, Granada 18014, Spain

[2] Hosp Univ Mostoles, Madrid 28935, Spain

[3] Hosp Univ Lucus Augusti, Lugo 27003, Spain

[4] Hosp Sagunto, Valencia 46520, Spain

[5] Hosp HM Policlin Rosaleda, Santiago De Compostela 15701, Spain

[6] Hosp Miguel Servet, Zaragoza 50009, Spain

[7] Hosp St Joan Deu, Barcelona 08950, Spain

[8] Inmunotek SL, Appl Sci, Madrid 28805, Spain

[9] Hosp Univ & Politecn La Fe, Valencia 46026, Spain

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2025年 / 26卷 / 07期

关键词：

aerobiology; exposome; allergens; allergic rhinitis; allergic asthma; climate change; EXPOSURE; PREVALENCE; ALLERGY; CHILDREN; POLLEN; RISK; AGE; RHINITIS; ASTHMA; IMPACT;

D O I：

10.3390/ijms26072963

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Spain exhibits significant climatic variability across its regions, ranging from the humid oceanic climate in the north to the Mediterranean and stepped climates in the southern and central areas. These climatic differences influence environmental allergen exposure, which may, in turn, affect allergic sensitization patterns in the pediatric population. Variations in temperature, humidity, and airborne allergen distribution, such as pollen, dust mites, animal epithelia, and mold, contribute to regional disparities in allergic responses among children. Understanding how climatic conditions shape allergen recognition patterns across different geographical areas is essential for improving allergy prevention and management strategies. This study aims to shed light on this issue by identifying sensitization patterns in a pediatric population of 236 patients (with 2 age groups analyzed: 6-10 and 11-15 years old) from different climatic regions of Spain. Skin tests with standard aeroallergens were performed, and specific IgE (sIgE) analysis by Allergy Explorer of Macroarray Diagnostic test (ALEX2) and Western blot. The results revealed different sensitization trends across patients from the eight cities analyzed (Barcelona, Granada, Lugo, Sagunto, Santiago de Compostela, Valencia, and Zaragoza).

引用

页数：21

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