Clinical high risk for psychosis in bipolar disorder: Clinical features, cognition and functioning

Bipolar disorder (BD) is a heterogeneous disease in terms of clinical course, neurocognitive and social-cognitive features, and functioning. Given the overlap between BD and schizophrenia, psychosis high-risk criteria that persist during euthymia may define a subgroup that differs in clinical features and functioning. In this study, we defined a subgroup of BD as ' Bipolar Disorder with Clinical High-Risk for Psychosis (BD-CHR-P)'. Our main aim was to investigate the differences in neurocognition, social cognition, psychosocial functioning, thought disorder, and clinical features in this subgroup and compare them with the BD group without this syndrome. 77 participants are included in this study. According to the Structured Interview for Prodromal Syndromes (SIPS), 25 participants were included in the BD-CHR-P group. Clinical features, cognition, functionality, thought disorder, apathy, impulsivity, and schizotypy were compared between the groups. Individuals with BD-CHR-P showed a higher rate of psychotic features in their manic episodes, and they displayed more Schneiderian symptoms in psychotic manic episodes (p = 0.049). BD-CHR-P group displayed worse functioning (F = 14.153, p < 0.001). The scores of anticipatory anhedonia (F = 5.27, p = 0.024) and positive formal thought disorder were higher in BD-CHR-P (F = 4.486, p = 0.037). In self-report evaluations impulsivity, self-report apathy, and schizotypy scores in the BD-CHR-P group were significantly higher than the BD-nonCHR-P group (F = 5.305, p = 0.024, F = 5.487, p = 0.022, F = 22.759, p < 0.001, respectively). The BD-CHR-P group exhibited poorer functioning. Further studies are needed to elucidate the mechanisms underlying the between-group differences. Moreover, cross-sectional characteristics of the BD-CHR-P group may help identify a subgroup that will develop psychotic disorders in the future.