Use of procalcitonin in therapeutic decisions in the pediatric intensive care unit

被引：0
|
作者：
Pierre Tissières [1 ]
Elisabeth Esteban Torné [2 ]
Johannes Hübner [3 ]
Adrienne G. Randolph [4 ]
Corsino Rey Galán [5 ]
Scott L. Weiss [6 ]
机构：
[1] IHU-PROMETHEUS Comprehensive Sepsis Center, Pediatric Intensive Care, Neonatal Medicine and Pediatric Emergency Department, AP-HP Paris Saclay University, Bicêtre Hospital, 78, Rue du General Leclerc, Le Kremlin-Bicêtre
[2] University of Barcelona, Hospital Sant Joan de Déu, Barcelona
[3] Ludwig-Maximilian-University, Hauner Children’s Hospital, Munich
[4] Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s Hospital, Boston, MA
[5] University of Oviedo, Hospital Universitario Central de Asturias (HUCA), Health Research Institute of the Principality of Asturias (ISPA), Oviedo
[6] Thomas Jefferson University, Nemours Children’s Health, Jacksonville, DE
来源：
Annals of Intensive Care | / 15卷 / 1期
基金：
美国国家卫生研究院;
关键词：
Bacterial infections; Pediatric intensive care units; Procalcitonin; Sepsis;
D O I：
10.1186/s13613-025-01470-y
中图分类号：
学科分类号：
摘要：
Procalcitonin (PCT) is frequently used by clinicians in children with suspected bacterial infections and sepsis. However interpretation in the critically ill child may be challenging due to the complexity of underlying conditions and its impact on PCT values. Herein, we propose a guidance for the use of procalcitonin in critically ill children, supported by a comprehensive analysis of the literature, to help the clinician for interpreting PCT in the various clinical conditions encountered in pediatric intensive care units. We describe the importance of the clinical context, timing of measurement and evidence on PCT values in diagnosing sepsis and to guide antibiotic therapy in critically ill children. © The Author(s) 2025.
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