Crossing Age Boundaries: The Unifying Potential of Presepsin in Sepsis Diagnosis Across Diverse Age Groups

被引:0
作者
de Moura, Edmilson Leal Bastos [1 ,2 ]
Pereira, Rinaldo Wellerson [1 ,3 ]
机构
[1] Univ Brasilia UnB, Hlth Sci Doctoral Program, BR-70910900 Brasilia, DF, Brazil
[2] Dist Fed Univ UnDF, Sch Hlth Sci, BR-70710907 Brasilia, DF, Brazil
[3] Univ Catolica Brasilia, Genom Sci & Biotechnol Grad Program, BR-71966700 Brasilia, DF, Brazil
关键词
sepsis; biomarkers; presepsin; elderly; neonates; adults; PERSONALIZED MEDICINE; NEONATAL SEPSIS; GLOBAL BURDEN; ONSET SEPSIS; PROCALCITONIN; BIOMARKERS; MORTALITY; ACCURACY; SCD14-ST; HOSPITALIZATION;
D O I
10.3390/jcm13237038
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Sepsis is a pervasive condition that affects individuals of all ages, with significant social and economic consequences. The early diagnosis of sepsis is fundamental for establishing appropriate treatment and is based on warning scores and clinical characteristics, with positive microbiological cultures being the gold standard. Research has yet to identify a single biomarker to meet this diagnostic demand. Presepsin is a molecule that has the potential as a biomarker for diagnosing sepsis. In this paper, we present a narrative review of the diagnostic and prognostic performance of presepsin in different age groups. Given its particularities, it is identified that presepsin is a potential biomarker for sepsis at all stages of life.
引用
收藏
页数:16
相关论文
共 130 条
  • [61] Sepsis biomarkers: past, present and future
    Lippi, Giuseppe
    [J]. CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2019, 57 (09) : 1281 - 1283
  • [62] Diagnostic value and prognostic evaluation of Presepsin for sepsis in an emergency department
    Liu, Bo
    Chen, Yun-Xia
    Yin, Qin
    Zhao, Yun-Zhou
    Li, Chun-Sheng
    [J]. CRITICAL CARE, 2013, 17 (05)
  • [63] Biomarkers for diagnosis of sepsis in patients with systemic inflammatory response syndrome: a systematic review and meta-analysis
    Liu, Yong
    Hou, Jun-huan
    Li, Qing
    Chen, Kui-jun
    Wang, Shu-Nan
    Wang, Jian-min
    [J]. SPRINGERPLUS, 2016, 5
  • [64] Enhancing sepsis biomarker development: key considerations from public and private perspectives
    Llitjos, Jean-Francois
    Carrol, Enitan D.
    Osuchowski, Marcin F.
    Bonneville, Marc
    Scicluna, Brendon P.
    Payen, Didier
    Randolph, Adrienne G.
    Witte, Stephan
    Rodriguez-Manzano, Jesus
    Francois, Bruno
    [J]. CRITICAL CARE, 2024, 28 (01)
  • [65] Usefulness of qSOFA and SIRS scores for detection of incipient sepsis in general ward patients: A prospective cohort study
    Luo, Jingchao
    Jiang, Wei
    Weng, Li
    Peng, Jinmin
    Hu, Xiaoyun
    Wang, Chunyao
    Liu, Guangyun
    Huang, Huibin
    Du, Bin
    [J]. JOURNAL OF CRITICAL CARE, 2019, 51 : 13 - 18
  • [66] The Emerging Role of Presepsin (P-SEP) in the Diagnosis of Sepsis in the Critically Ill Infant: A Literature Review
    Maddaloni, Chiara
    De Rose, Domenico Umberto
    Santisi, Alessandra
    Martini, Ludovica
    Caoci, Stefano
    Bersani, Iliana
    Ronchetti, Maria Paola
    Auriti, Cinzia
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (22)
  • [67] The effect of age on the development and outcome of adult sepsis
    Martin, GS
    Mannino, DM
    Moss, M
    [J]. CRITICAL CARE MEDICINE, 2006, 34 (01) : 15 - 21
  • [68] Sepsis and Immunosenescence in the Elderly Patient: A Review
    Martin, Silvia
    Perez, Alba
    Aldecoa, Cesar
    [J]. FRONTIERS IN MEDICINE, 2017, 4
  • [69] Risk factors for mortality in elderly and very elderly critically ill patients with sepsis: a prospective, observational, multicenter cohort study
    Martin-Loeches, Ignacio
    Guia, Maria Consuelo
    Vallecoccia, Maria Sole
    Suarez, David
    Ibarz, Mercedes
    Irazabal, Marian
    Ferrer, Ricard
    Artigas, Antonio
    [J]. ANNALS OF INTENSIVE CARE, 2019, 9 (1)
  • [70] Maruna P, 2000, PHYSIOL RES, V49, pS57