Host biomarkers and parasite biomass are associated with severe malaria in Mozambican children: a case-control study

被引：0

作者：

Varo, Rosauro ^{[1
,2
]}

Sitoe, Antonio ^{[2
]}

Madrid, Lola ^{[3
]}

Aide, Pedro ^{[2
]}

Cuamba, Inocencia ^{[2
]}

Cossa, Anelsio ^{[2
]}

Jairoce, Chenjerai ^{[2
]}

Barrios, Diana ^{[1
]}

Martianez-Vendrell, Xavier ^{[1
]}

Balanza, Nuria ^{[1
]}

Cistero, Pau ^{[1
]}

Ouchi, Dan ^{[1
]}

Quinto, Llorenc ^{[1
]}

Crowley, Valerie M. ^{[4
]}

Gupta, Himanshu ^{[5
]}

Kain, Kevin C. ^{[6
,7
,8
]}

Mayor, Alfredo ^{[1
,2
,9
,10
]}

Bassat, Quique ^{[1
,2
,11
,12
,13
,14
]}

机构：

[1] Univ Barcelona, Barcelona Inst Global Hlth, Barcelona Inst Global Hlth ISGlobal, Hosp Clin, Carrer Rossello 132,5th 2nd, Barcelona 08036, Spain

[2] Ctr Invest Saude Manhica CISM, Maputo, Mozambique

[3] London Sch Hyg & Trop Med, London, England

[4] Univ Hlth Network, Toronto Gen Hosp, Sandra Rotman Ctr Global Hlth, SA Rotman Labs, Toronto, ON, Canada

[5] GLA Univ, Inst Appl Sci & Humanities, Dept Biotechnol, Mathura, India

[6] Univ Hlth Network, Toronto Gen Res Inst TGRI, Toronto, ON, Canada

[7] Univ Toronto, Dept Med, Toronto, ON, Canada

[8] Toronto Gen Hosp, Dept Med, Div Infect Dis, Trop Dis Unit,UHN, Toronto, ON, Canada

[9] Inst Salud Carlos III, CIBER Epidemiol & Salud Publ, Madrid, Spain

[10] Univ Eduardo Mondlane, Fac Med, Dept Physiol Sci, Maputo, Mozambique

[11] ICREA, Pg Lluis Companys 23, Barcelona 08010, Spain

[12] Hosp Clin Barcelona, Inst Clin Med Dermatol i, Barcelona, Spain

[13] Univ Barcelona UB, Fac Med & Ciencies Salut, Barcelona, Spain

[14] Univ Barcelona, Hosp Sant Joan de Deu, Pediat Dept, Pediat Infect Dis Unit, Barcelona, Spain

来源：

SCIENTIFIC REPORTS | 2025年 / 15卷 / 01期

关键词：

Severe malaria; Risk-stratification; Pediatric; HRP-2; Endothelial activation; Host biomarkers; PLASMODIUM-FALCIPARUM MALARIA; HISTIDINE-RICH PROTEIN-2; CEREBRAL MALARIA; HIGH-TRANSMISSION; RETINOPATHY; MORTALITY; CYTOKINES; PFHRP2;

D O I：

10.1038/s41598-025-98154-1

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Severe pediatric malaria remains a pressing global health issue. Laboratory parameters may provide early risk and severity stratification for better disease management, beyond current clinical severity scores. This study aimed to identify host biomarkers of immune and endothelial activation and parasite biomass in children with severe malaria (SM) compared to uncomplicated malaria (UM). We conducted a case-control study in a rural hospital in southern Mozambique from 2014 to 2016, recruiting patients under 10 years old with Plasmodium falciparum SM as cases, and patients with UM matched by age, sex, and parasitemia as controls. We compared plasma levels of biomarkers associated with total parasite mass (HRP-2), biomarkers of host response to infection (Angpt-1, Angpt-2, sTie-2, BDNF, CysC, sFlt-1, IL-6, IL-8, IP-10, sTNFR-1 and sTREM-1). All biomarker levels except Angpt-1, BDNF and CysC were significantly higher in children with SM. HRP-2 levels significantly differed between cases and controls, strongly correlating with Angpt-2, sTie-2, sFlt-1, TNRF, and sTREM-1, both in SM and UM. In conclusion, host biomarkers indicative of immune and endothelial activation were associated with malaria severity and HRP-2, even after controlling for matching variables, potentially offering targets for risk-stratification and adjuvant therapy.

引用

页数：11

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