A 58-year-old man, initially treated for erectile dysfunction, presented with erosion of a penile prosthesis through the urethra one year after his surgical intervention. Clinical examination revealed the extrusion of the left penile prosthesis through the urethral meatus, associated with mild local inflammation and a fever of 39 degrees C. The patient underwent manual extraction of the prosthesis, careful and delicate urethral catheterization, and antibiotic therapy. Two months later, he was readmitted for the insertion of a new penile prosthesis in the left corpora cavernosa and was discharged on the second postoperative day without complications. Thus, erosion of a penile prosthesis is a serious complication requiring prompt removal of the prosthesis, effective antibiotic treatment, and proper urethral healing.