Comparative Evaluation of the Functional Potential of Mesenchymal Stem Cells from the Bichat’s Fat Pad, Bone Marrow, and Adipose Tissue for Bone Tissue Regeneration

被引：0
作者：
N. A. Bondarenko [1 ]
M. A. Surovtseva [1 ]
I. I. Kim [1 ]
S. V. Ostapets [2 ]
O. S. Kosareva [2 ]
M. N. Drovosekov [2 ]
O. V. Poveshchenko [1 ]
机构：
[1] Scientific Institution of Clinical and Experimental Lymphology – Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk
[2] Novosibirsk State Medical University, Ministry of Health of the Russian Federation, Novosibirsk
来源：
Bulletin of Experimental Biology and Medicine | 2025年 / 178卷 / 5期
关键词：
Bichat’s fat pad; erythropoietin; mesenchymal stem cells; osteogenic differentiation; proliferation;
D O I：
10.1007/s10517-025-06378-y
中图分类号：
学科分类号：
摘要：
The functional potential of mesenchymal stem cells (MSC) isolated from Bichat’s fat pad for osteoinduction in dentistry was compared with that of MSC from the adipose tissue and bone marrow. Functional activity of MSC was evaluated by the rate of their proliferation, migration, and differentiation into osteoblasts under the influence of erythropoietin. MSC from the Bichat’s fat pad have higher proliferative activity than MSC from the adipose tissue or bone marrow under the influence of platelet-enriched plasma. Moreover, they are characterized by low migration activity, differentiate into osteoblasts, and intensively produce alkaline phosphatase under the influence of erythropoietin. The revealed functional potential of MSC from the Bichat’s fat pad makes them promising for cell therapy, including osteoinduction in dentistry. © Springer Science+Business Media, LLC, part of Springer Nature 2025.
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页码：581 / 585
页数：4
相关论文
共 18 条
  • [1] Orbay H., Tobita M., Mizuno H., Mesenchymal stem cells isolated from adipose and other tissues: basic biological properties and clinical applications, Stem Cells Int, 2012, (2012)
  • [2] Genova T., Cavagnetto D., Tasinato F., Et al., Isolation and characterization of buccal fat pad and dental pulp MSCs from the same donor, Biomedicines, 9, 3, (2021)
  • [3] Meshram M., Anchlia S., Shah H., Et al., Buccal fat pad-derived stem cells for repair of maxillofacial bony defects, J Maxillofac Oral Surg, 18, 1, pp. 112-123, (2019)
  • [4] Khojasteh A., Hosseinpour S., Rezai Rad M., Et al., Buccal fat pad-derived stem cells with anorganic bovine bone mineral scaffold for augmentation of atrophic posterior mandible: an exploratory prospective clinical study, Clin Implant Dent Relat Res, 21, 2, pp. 292-300, (2019)
  • [5] Rohrich R.J., Pessa J.E., The anatomy and clinical implications of perioral submuscular fat, Plast Reconstr Surg, 124, 1, pp. 266-271, (2009)
  • [6] Camacho-Alonso F., Tudela-Mulero M.R., Navarro J.A., Et al., Use of buccal fat pad-derived stem cells cultured on bioceramics for repair of critical-sized mandibular defects in healthy and osteoporotic rats, Clin Oral Investig, 26, 8, pp. 5389-5408, (2022)
  • [7] Broccaioli E., Niada S., Rasperini G., Et al., Mesenchymal stem cells from Bichat’s fat pad: in vitro comparison with adipose-derived stem cells from subcutaneous tissue, Biores Open Access, 2, 2, pp. 107-117, (2013)
  • [8] Lykov A.P., Poveshchenko O.V., Bondarenko N.A., Et al., Therapeutic potential of fibroblast combined with platelet-rich plasma on burn skin wound healing, J Biol Today’s World, 8, 1, pp. 1-5, (2019)
  • [9] Lykov A.P., Bondarenko N.A., Surovtseva M.A., Et al., Comparative effects of platelet-rich plasma, platelet lysate, and fetal calf serum on mesenchymal stem cells, Bull Exp Biol Med, 163, 6, pp. 757-760, (2017)
  • [10] Salehi-Nik N., Rezai Rad M., Kheiri L., Et al., Buccal fat pad as a potential source of stem cells for bone regeneration: a literature review, Stem Cells Int, 2017, (2017)
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