Lactate metabolism and lactylation in breast cancer: mechanisms and implications

被引：0

作者：

Qiao, Yifan ^{[1
,2
,3
]}

Liu, Yijia ^{[1
,2
,3
]}

Ran, Ran ^{[1
,2
,3
]}

Zhou, Yan ^{[1
,2
,3
]}

Gong, Jin ^{[1
,2
,3
]}

Liu, Lijuan ^{[1
,2
,3
]}

Zhang, Yusi ^{[1
,2
,3
]}

Wang, Hui ^{[1
,2
,3
]}

Fan, Yuan ^{[1
,2
,3
]}

Fan, Yihan ^{[1
,2
,3
]}

Nan, Gengrui ^{[1
,2
,3
]}

Zhang, Peng ^{[4
,5
]}

Yang, Jin ^{[1
,2
,3
]}

机构：

[1] Xi An Jiao Tong Univ, Canc Ctr, Affiliated Hosp 1, Xian, Peoples R China

[2] Xi An Jiao Tong Univ, Precis Med Ctr, Affiliated Hosp 1, Xian, Peoples R China

[3] Xi An Jiao Tong Univ, Dept Med Oncol, Affiliated Hosp 1, Xian, Peoples R China

[4] Nanchang Univ, Affiliated Hosp 1, Jiangxi Med Coll, Ctr Mol Diag & Precis Med, 1519 Dongyue Dadao, Nanchang 330209, Peoples R China

[5] Nanchang Univ, Affiliated Hosp 1, Jiangxi Med Coll, Jiangxi Prov Ctr Adv Diagnost Technol & Precis Med, 1519 Dongyue Dadao, Nanchang 330209, Peoples R China

来源：

CANCER AND METASTASIS REVIEWS | 2025年 / 44卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Breast cancer; Lactate; Lactylation; TME; Drugs; TUMOR-ASSOCIATED MACROPHAGES; PYRUVATE-KINASE M2; GENE-EXPRESSION; DEHYDROGENASE; TRANSPORTER; INHIBITORS; GLYCOLYSIS; MIGRATION; INTERPLAY; GROWTH;

D O I：

10.1007/s10555-025-10264-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

As the end-product of glycolysis, lactate serves as a regulator of protein lactylation in addition to being an energy substrate, metabolite, and signaling molecule in cancer. The reprogramming of glucose metabolism and the Warburg effect in breast cancer results in extensive lactate production and accumulation, making it likely that lactylation in tumor tissue is also abnormal. This review summarizes evidence on lactylation derived from studies of lactate metabolism and disease, highlighting the role of lactate in the tumor microenvironment of breast cancer and detailing the levels of lactylation and cancer-promoting mechanisms across various tumors. The roles of lactate and lactylation, along with potential intervention mechanisms, are presented and discussed, offering valuable insights for future research on the role of lactylation in tumors.

引用

页数：24

共 50 条

[41] Integrin β1 in breast cancer: mechanisms of progression and therapy
Huang, Qionglian
Wang, Jue
Ning, Hanjuan
Liu, Weiwei
Han, Xianghui
BREAST CANCER, 2025, 32 (01) : 43 - 59
[42] Lactate mediated metabolic crosstalk between cancer and immune cells and its therapeutic implications
Mortazavi Farsani, Seyedeh Sahar
Verma, Vivek
FRONTIERS IN ONCOLOGY, 2023, 13
[43] Appraising histone H4 lysine 5 lactylation as a novel biomarker in breast cancer
Zhu, Ya
Fu, Yuping
Liu, Fengzhen
Yan, Sha
Yu, Ruili
SCIENTIFIC REPORTS, 2025, 15 (01):
[44] Demethylzeylasteral targets lactate to suppress the tumorigenicity of liver cancer stem cells: It is attributed to histone lactylation?
Gong, Hang
Xu, Hui-Mei
Ma, Yao-Hui
Zhang, De-Kui
PHARMACOLOGICAL RESEARCH, 2023, 194
[45] Lysine lactylation (Kla) might be a novel therapeutic target for breast cancer
Jian Deng
Xinyi Liao
BMC Medical Genomics, 16
[46] Regulatory role and therapeutic prospect of lactate modification in cancer
Sun, Mengdi
Wang, Kejing
Lu, Fang
Yu, Donghua
Liu, Shumin
FRONTIERS IN PHARMACOLOGY, 2025, 16
[47] Functional mechanisms and potential therapeutic strategies for lactylation in liver diseases
Xu, Rong
Hao, Yitong
Liu, Yahui
Ji, Bai
Tian, Weibo
Zhang, Wei
LIFE SCIENCES, 2025, 363
[48] Breast cancer combined prognostic model based on lactate metabolism genes
Lu, Na
Guan, Xiao
Bao, Wei
Fan, Zongyao
Zhang, Jianping
MEDICINE, 2022, 101 (51)
[49] Lactate promotes H3K18 lactylation in human neuroectoderm differentiation
Wu, Yu
Wang, Yumeng
Dong, Yuhao
Sun, Ling V.
Zheng, Yufang
CELLULAR AND MOLECULAR LIFE SCIENCES, 2024, 81 (01)
[50] The Metabolic Mechanisms of Breast Cancer Metastasis
Wang, Lingling
Zhang, Shizhen
Wang, Xiaochen
FRONTIERS IN ONCOLOGY, 2021, 10

← 1 2 3 4 5 →