Lactate metabolism and lactylation in breast cancer: mechanisms and implications

被引：0
|
作者：
Qiao, Yifan [1 ,2 ,3 ]
Liu, Yijia [1 ,2 ,3 ]
Ran, Ran [1 ,2 ,3 ]
Zhou, Yan [1 ,2 ,3 ]
Gong, Jin [1 ,2 ,3 ]
Liu, Lijuan [1 ,2 ,3 ]
Zhang, Yusi [1 ,2 ,3 ]
Wang, Hui [1 ,2 ,3 ]
Fan, Yuan [1 ,2 ,3 ]
Fan, Yihan [1 ,2 ,3 ]
Nan, Gengrui [1 ,2 ,3 ]
Zhang, Peng [4 ,5 ]
Yang, Jin [1 ,2 ,3 ]
机构：
[1] Xi An Jiao Tong Univ, Canc Ctr, Affiliated Hosp 1, Xian, Peoples R China
[2] Xi An Jiao Tong Univ, Precis Med Ctr, Affiliated Hosp 1, Xian, Peoples R China
[3] Xi An Jiao Tong Univ, Dept Med Oncol, Affiliated Hosp 1, Xian, Peoples R China
[4] Nanchang Univ, Affiliated Hosp 1, Jiangxi Med Coll, Ctr Mol Diag & Precis Med, 1519 Dongyue Dadao, Nanchang 330209, Peoples R China
[5] Nanchang Univ, Affiliated Hosp 1, Jiangxi Med Coll, Jiangxi Prov Ctr Adv Diagnost Technol & Precis Med, 1519 Dongyue Dadao, Nanchang 330209, Peoples R China
来源：
CANCER AND METASTASIS REVIEWS | 2025年 / 44卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Breast cancer; Lactate; Lactylation; TME; Drugs; TUMOR-ASSOCIATED MACROPHAGES; PYRUVATE-KINASE M2; GENE-EXPRESSION; DEHYDROGENASE; TRANSPORTER; INHIBITORS; GLYCOLYSIS; MIGRATION; INTERPLAY; GROWTH;
D O I：
10.1007/s10555-025-10264-4
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
As the end-product of glycolysis, lactate serves as a regulator of protein lactylation in addition to being an energy substrate, metabolite, and signaling molecule in cancer. The reprogramming of glucose metabolism and the Warburg effect in breast cancer results in extensive lactate production and accumulation, making it likely that lactylation in tumor tissue is also abnormal. This review summarizes evidence on lactylation derived from studies of lactate metabolism and disease, highlighting the role of lactate in the tumor microenvironment of breast cancer and detailing the levels of lactylation and cancer-promoting mechanisms across various tumors. The roles of lactate and lactylation, along with potential intervention mechanisms, are presented and discussed, offering valuable insights for future research on the role of lactylation in tumors.
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页数：24
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