Macrophage-derived exosomes in cancer: a double-edged sword with therapeutic potential

被引：0

作者：

Long Liu ^{[1
]}

Siying Zhang ^{[2
]}

Yuqing Ren ^{[3
]}

Ruizhi Wang ^{[4
]}

Yuyuan Zhang ^{[3
]}

Siyuan Weng ^{[1
]}

Zhaokai Zhou ^{[1
]}

Peng Luo ^{[5
]}

Quan Cheng ^{[6
]}

Hui Xu ^{[7
]}

Yuhao Ba ^{[1
]}

Anning Zuo ^{[1
]}

Shutong Liu ^{[1
]}

Zaoqu Liu ^{[1
]}

Xinwei Han ^{[1
]}

机构：

[1] Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Henan, Zhengzhou

[2] Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Shaanxi, Xi’an

[3] Medical School of Zhengzhou University, Henan, Zhengzhou

[4] Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University, Henan, Zhengzhou

[5] Department of Urology, The First Affiliated Hospital of Zhengzhou University, Henan, Zhengzhou

[6] The Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou

[7] Department of Neurosurgery, Xiangya Hospital, Central South University, Hunan, Changsha

[8] Interventional Institute of Zhengzhou University, Henan, Zhengzhou

[9] Interventional Treatment and Clinical Research Center of Henan Province, Henan, Zhengzhou

[10] Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing

来源：

Journal of Nanobiotechnology | / 23卷 / 1期

关键词：

Cancer therapy; Exosomes; Macrophage-derived exosomes; Modified exosomes; Tumor-associated macrophages;

D O I：

10.1186/s12951-025-03321-1

中图分类号：

学科分类号：

摘要：

Solid cancer contains a complicated communication network between cancer cells and components in the tumor microenvironment (TME), significantly influencing the progression of cancer. Exosomes function as key carriers of signaling molecules in these communications, including the intricate signalings of tumor-associated macrophages (TAMs) on cancer cells and the TME. With their natural lipid bilayer structures and biological activity that relates to their original cell, exosomes have emerged as efficient carriers in studies on cancer therapy. Intrigued by the heterogeneity and plasticity of both macrophages and exosomes, we regard macrophage-derived exosomes in cancer as a double-edged sword. For instance, TAM-derived exosomes, educated by the TME, can promote resistance to cancer therapies, while macrophage-derived exosomes generated in vitro have shown favorable potential in cancer therapy. Here, we depict the reasons for the heterogeneity of TAM-derived exosomes, as well as the manifold roles of TAM-derived exosomes in cancer progression, metastasis, and resistance to cancer therapy. In particular, we emphasize the recent advancements of modified macrophage-derived exosomes in diverse cancer therapies, arguing that these modified exosomes are endowed with unique advantages by their macrophage origin. We outline the challenges in translating these scientific discoveries into clinical cancer therapy, aiming to provide patients with safe and effective treatments. © The Author(s) 2025.

引用

共 169 条

[61] Hoshino A., Costa-Silva B., Shen T.-L., Rodrigues G., Hashimoto A., Tesic Mark M., Et al., Tumour exosome integrins determine organotropic metastasis, Nature, 527, 7578, pp. 329-335, (2015)
[62] Xu G., Xu S., Shi X., Shen C., Zhang D., Zhang T., Et al., Foot-and-mouth disease virus degrades Rab27a to suppress the exosome-mediated antiviral immune response, Vet Microbiol, 251, (2020)
[63] Shimizu A., Sawada K., Kobayashi M., Yamamoto M., Yagi T., Kinose Y., Et al., Exosomal CD47 plays an essential role in immune evasion in ovarian cancer, Mol Cancer Res MCR, 19, 9, (2021)
[64] Ma X., Zhao J., Li S., Wang Y., Liu J., Shi Y., Et al., Rab27a-dependent exosomes protect against cerebral ischemic injury by reducing endothelial oxidative stress and apoptosis, CNS Neurosci Ther, 28, 10, (2022)
[65] Park M.D., Silvin A., Ginhoux F., Merad M., Macrophages in health and disease, Cell, 185, 23, (2022)
[66] Wculek S.K., Dunphy G., Heras-Murillo I., Mastrangelo A., Sancho D., Metabolism of tissue macrophages in homeostasis and pathology, Cell Mol Immunol, 19, 3, pp. 384-408, (2022)
[67] Chen S., Saeed A.F.U.H., Liu Q., Jiang Q., Xu H., Xiao G.G., Et al., Macrophages in immunoregulation and therapeutics, Signal Transduct Target Ther, 8, 1, (2023)
[68] Mills C.D., Kincaid K., Alt J.M., Heilman M.J., Hill A.M., M-1/M-2 macrophages and the Th1/Th2 paradigm, J Immunol, 164, 12, pp. 6166-6173, (2000)
[69] Strizova Z., Benesova I., Bartolini R., Novysedlak R., Cecrdlova E., Foley L.K., Et al., M1/M2 macrophages and their overlaps - myth or reality?, Clin Sci, 137, 15, pp. 1067-1093, (2023)
[70] Cho U., Kim B., Kim S., Han Y., Song Y.S., Pro-inflammatory M1 macrophage enhances metastatic potential of ovarian cancer cells through NF-κB activation, Mol Carcinog, 57, 2, pp. 235-242, (2018)

← 2 3 4 5 6 7 8 9 10 11 →