Macrophage-derived exosomes in cancer: a double-edged sword with therapeutic potential

被引：0

作者：

Long Liu ^{[1
]}

Siying Zhang ^{[2
]}

Yuqing Ren ^{[3
]}

Ruizhi Wang ^{[4
]}

Yuyuan Zhang ^{[3
]}

Siyuan Weng ^{[1
]}

Zhaokai Zhou ^{[1
]}

Peng Luo ^{[5
]}

Quan Cheng ^{[6
]}

Hui Xu ^{[7
]}

Yuhao Ba ^{[1
]}

Anning Zuo ^{[1
]}

Shutong Liu ^{[1
]}

Zaoqu Liu ^{[1
]}

Xinwei Han ^{[1
]}

机构：

[1] Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Henan, Zhengzhou

[2] Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Shaanxi, Xi’an

[3] Medical School of Zhengzhou University, Henan, Zhengzhou

[4] Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University, Henan, Zhengzhou

[5] Department of Urology, The First Affiliated Hospital of Zhengzhou University, Henan, Zhengzhou

[6] The Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou

[7] Department of Neurosurgery, Xiangya Hospital, Central South University, Hunan, Changsha

[8] Interventional Institute of Zhengzhou University, Henan, Zhengzhou

[9] Interventional Treatment and Clinical Research Center of Henan Province, Henan, Zhengzhou

[10] Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing

来源：

Journal of Nanobiotechnology | / 23卷 / 1期

关键词：

Cancer therapy; Exosomes; Macrophage-derived exosomes; Modified exosomes; Tumor-associated macrophages;

D O I：

10.1186/s12951-025-03321-1

中图分类号：

学科分类号：

摘要：

Solid cancer contains a complicated communication network between cancer cells and components in the tumor microenvironment (TME), significantly influencing the progression of cancer. Exosomes function as key carriers of signaling molecules in these communications, including the intricate signalings of tumor-associated macrophages (TAMs) on cancer cells and the TME. With their natural lipid bilayer structures and biological activity that relates to their original cell, exosomes have emerged as efficient carriers in studies on cancer therapy. Intrigued by the heterogeneity and plasticity of both macrophages and exosomes, we regard macrophage-derived exosomes in cancer as a double-edged sword. For instance, TAM-derived exosomes, educated by the TME, can promote resistance to cancer therapies, while macrophage-derived exosomes generated in vitro have shown favorable potential in cancer therapy. Here, we depict the reasons for the heterogeneity of TAM-derived exosomes, as well as the manifold roles of TAM-derived exosomes in cancer progression, metastasis, and resistance to cancer therapy. In particular, we emphasize the recent advancements of modified macrophage-derived exosomes in diverse cancer therapies, arguing that these modified exosomes are endowed with unique advantages by their macrophage origin. We outline the challenges in translating these scientific discoveries into clinical cancer therapy, aiming to provide patients with safe and effective treatments. © The Author(s) 2025.

引用

共 169 条

[1] Kalluri R., McAndrews K.M., The role of extracellular vesicles in cancer, Cell, 186, 8, pp. 1610-1626, (2023)
[2] Kalluri R., LeBleu V.S., The biology, function, and biomedical applications of exosomes, Science, 367, 6478, (2020)
[3] Arya S.B., Collie S.P., Parent C.A., The ins-and-outs of exosome biogenesis, secretion, and internalization, Trends Cell Biol, S0962–8924, 23, (2023)
[4] Cheng L., Hill A.F., Therapeutically harnessing extracellular vesicles, Nat Rev Drug Discovery, 21, 5, pp. 379-399, (2022)
[5] Christofides A., Strauss L., Yeo A., Cao C., Charest A., Boussiotis V.A., The complex role of tumor-infiltrating macrophages, Nat Immunol, 23, 8, pp. 1148-1156, (2022)
[6] Kloosterman D.J., Akkari L., Macrophages at the interface of the co-evolving cancer ecosystem, Cell, 186, 8, pp. 1627-1651, (2023)
[7] Mantovani A., Allavena P., Marchesi F., Garlanda C., Macrophages as tools and targets in cancer therapy, Nat Rev Drug Discovery, 21, 11, pp. 799-820, (2022)
[8] Cassetta L., Pollard J.W., A timeline of tumour-associated macrophage biology, Nat Rev Cancer, 23, 4, pp. 238-257, (2023)
[9] Pittet M.J., Michielin O., Migliorini D., Clinical relevance of tumour-associated macrophages, Nat Rev Clin Oncol, 19, 6, pp. 402-421, (2022)
[10] Zhou M., He X., Mei C., Ou C., Exosome derived from tumor-associated macrophages: biogenesis, functions, and therapeutic implications in human cancers, Biomarker Res, 11, 1, (2023)

← 1 2 3 4 5 6 7 8 9 10 →