Predictive models and WTAP targeting for idiopathic pulmonary fibrosis (IPF)

被引:0
作者
Li, Guo-Dong [1 ]
Li, Juan [2 ]
Fan, Jia-Qi [3 ]
Li, Jun-Yi [4 ]
Zhao, Bin [5 ]
Chen, Xiao [1 ]
机构
[1] Qingdao Univ, Affiliated Taian City Cent Hosp, Dept Pulm & Crit Care Med, Longtan Rd 29, Tai An 271000, Peoples R China
[2] Qingdao Univ, Affiliated Taian City Cent Hosp, Dept Comprehens Ward, Tai An, Peoples R China
[3] Jining Med Univ, 133 Hehua Rd, Jining, Peoples R China
[4] Nanchang Univ, Clin Med Coll 2, Nanchang, Peoples R China
[5] Qingdao Univ, Affiliated Taian City Cent Hosp, Pediat Surg, Longtan Rd 29, Tai An 271000, Peoples R China
关键词
Idiopathic pulmonary fibrosis; Immune cell infiltration; Molecular docking; WTAP; Prognostic biomarker;
D O I
10.1038/s41598-025-98490-2
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Emerging evidence suggests that N6-methyladenosine (m6A) modification significantly influences lung injury, lung cancer, and immune responses. The current study explores the potential involvement of m6A modification in the development of IPF. This research analyzed the GSE93606 dataset of 20 non-IPF and 154 IPF patients, identifying 26 m6A regulators and developing predictive models with RF and SVM, assessed via ROC curves. A nomogram was created with selected m6A factors, including molecular subtyping, PCA for m6A features, immune cell analysis, DEG identification, and functional enrichment. In vitro experiments on MRC-5 cells used RT-qPCR and Western blotting, and virtual drug screening targeted the WTAP protein through molecular docking. Analysis revealed 26 differential m6A regulators in IPF patients, with 16 significant; IGFBP2 and YTHDF2 were overexpressed, while others decreased. RF and SVM models identified predictive m6A regulators, and a nomogram was developed using five factors to predict IPF incidence. Distinct m6A patterns showed changes in RNA levels of specific genes in the BLM-induced group, and five compounds targeting WTAP were identified. This research explored m6A factors' impact on IPF diagnosis and prognosis, identifying WTAP as a potential biomarker.
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页数:19
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