Antibiotic residues correlate with antibiotic resistance of Salmonella typhimurium isolated from edible chicken meat

被引:0
作者
Ali, Hala R. [1 ]
Hefny, Esraa G. [2 ]
Koraney, Naglaa F. [1 ]
Ali, Samah F. [1 ]
AbdAllah, Mohamed I. [3 ]
Fadel, Mai A. [4 ]
Elnomrosy, Sara M. [3 ]
Shahein, Momataz A. [5 ]
机构
[1] Agr Res Ctr ARC, Anim Hlth Res Inst AHRI, Bacteriol Dept, Giza 12618, Egypt
[2] Agr Res Ctr ARC, Anim Hlth Res Inst AHRI, Food Hyg Dept, Giza 12618, Egypt
[3] Anim Hlth Res Inst AHRI, Agr Res Ctr ARC, Genome Res Unit, Nadi El Said St, Giza 12618, Egypt
[4] Agr Res Ctr ARC, Anim Hlth Res Inst AHRI, Dept Biochem Toxicol & Feed Deficiency, Pharmacol & Pyrogen Unit, POB 12618, Giza, Egypt
[5] Agr Res Ctr ARC, Anim Hlth Res Inst, Dept Virol Res, Giza 12618, Egypt
关键词
Salmonella; S; typhimurium; Antimicrobials; Antibiotic residues;
D O I
10.1038/s41598-025-98189-4
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Irrational application and overuse of antibiotics in poultry production is associated with antibiotic residues in meat tissues which lead to the development of antibiotic resistance in pathogenic bacteria such as Salmonella. This study investigated the co-existence of multi-drug resistant Salmonella typhimurium (S. typhimurium) and residual traces of antibiotics in chilled chicken meat collected from Fayoum province in Egypt. Our data reported that 22.2% of chicken meat and liver were contaminated with S. typhimurium with 100% being drug resistant to a wide range of antimicrobials including tylosin, chloramphenicol, and oxytetracycline (OTC). The residual analysis of chicken meat samples revealed that they contained residues of 3antibacterial drugs including tylosin, chloramphenicol, OTC and its metabolite (4-epi-OTC). The statistical analysis of obtained data also revealed a relationship between S. typhimurium resistance and the presence of antibiotic residues in chicken samples, as isolates derived from samples with residual drug content higher than maximum residue levels (MRL) were found to be resistant to the same antibiotic. This confirms the importance of integrating sustainable practices in the veterinary field with a strict commitment to monitoring the bacterial content and residual antibiotics in foods of animal origin before marketing them, to protect the effectiveness of antibiotics for future generations.
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页数:12
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