Highly pathogenic avian influenza H5N1: history, current situation, and outlook

被引：11

作者：

Krammer, Florian ^{[1
,2
,3
,4
]}

Hermann, Enikoe ^{[4
]}

Rasmussen, Angela L. ^{[5
,6
,7
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dept Microbiol, New York, NY 10029 USA

[2] Icahn Sch Med Mt Sinai, Ctr Vaccine Res & Pandem Preparedness C VaRPP, New York, NY 10029 USA

[3] Icahn Sch Med Mt Sinai, Dept Pathol Mol & Cell Based Med, New York, NY 10029 USA

[4] Med Univ Vienna, Ignaz Semmelweis Inst, Interuniv Inst Infect Res, Vienna, Austria

[5] Univ Saskatchewan, Vaccine & Infect Dis Org, Saskatoon, SK, Canada

[6] Univ Saskatchewan, Dept Biochem Microbiol & Immunol, Saskatoon, SK, Canada

[7] SUNY Stony Brook, Dept Ecol & Evolut, Stony Brook, NY 11794 USA

来源：

JOURNAL OF VIROLOGY | 2025年 / 99卷 / 04期

基金：

加拿大健康研究院; 美国国家卫生研究院;

关键词：

influenza virus; avian viruses; virus-host interactions; zoonotic infections; viral pathogenesis; pandemic risk; evolution; reassortment; influenza vaccines; HEMAGGLUTININ GENE; NORTH-AMERICAN; A(H5N1) VIRUS; H1N1; VIRUS; INFECTION; VACCINES; SPREAD; TRANSMISSION; MORTALITY; VIRULENCE;

D O I：

10.1128/jvi.02209-24

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The H5N1 avian panzootic has resulted in cross-species transmission to birds and mammals, causing outbreaks in wildlife, poultry, and US dairy cattle with a range of host-dependent pathogenic outcomes. Although no human-to-human transmission has been observed, the rising number of zoonotic human cases creates opportunities for adaptive mutation or reassortment. This Gem explores the history, evolution, virology, and epidemiology of clade 2.3.4.4b H5N1 relative to its pandemic potential. Pandemic risk reduction measures are urgently required.

引用

页数：14

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