Dopamine transporter imaging to predict the risk of aspiration in patients with Parkinson's disease

被引：0
作者：
Tanimura, Jun [1 ,2 ]
Yamamoto, Toshiyuki [1 ]
Shigemoto, Yoko [3 ]
Sato, Noriko [3 ]
Takahashi, Yuji [1 ]
机构：
[1] Natl Ctr Hosp, Natl Ctr Neurol & Psychiat NCNP, Dept Neurol, 4-1-1 Ogawa Higashicho, Kodaira, Tokyo 1878551, Japan
[2] Aizawa Hosp, Dept Neurol, 2-5-1 Honjo, Matsumoto, Nagano 3908510, Japan
[3] Natl Ctr Hosp, Natl Ctr Neurol & Psychiat NCNP, Dept Radiol, 4-1-1 Ogawa Higashicho, Kodaira, Tokyo 1878551, Japan
来源：
PARKINSONISM & RELATED DISORDERS | 2025年 / 132卷
基金：
日本学术振兴会;
关键词：
Parkinson's disease; Aspiration; Videofluoroscopic swallowing examinations; Dopamine transporter imaging; Specific binding ratio; SWALLOWING DYSFUNCTION; DYSPHAGIA; PROGRESSION; LEVODOPA;
D O I：
10.1016/j.parkreldis.2025.107307
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Introduction: Aspiration is a critical complication of dysphagia in Parkinson's disease (PD). Current methods for predicting aspiration are unsuitable for routine implementation owing to time constraints, cost, or insufficient predictive accuracy. We assessed the predictive performance of clinical measures, including dopamine transporter (DaT) imaging, for aspiration risk in patients with PD. Methods: We retrospectively analyzed data from patients with PD who underwent videofluoroscopic swallowing examinations (VF) and DaT imaging within 12 months. Patients were divided into aspiration and non-aspiration groups based on VF findings. Logistic regression and receiver operating characteristic (ROC) analyses evaluated the predictive performance of DaT imaging parameters including striatal specific binding ratio (SBR) and sub- regional SBRs, calculated using DaT View and DaTQUANT software. Results: Among 87 patients (38 females; mean age: 64 years; disease duration: 8.3 years [range: 1-20 years]; modified Hoehn and Yahr stages: 2 [range: 1-4]), 14.9 % experienced aspiration. DaT View striatal SBRs consistently showed significantly lower values in the aspiration group and negative associations with aspiration in logistic regression models, whereas DaTQUANT exhibited limited significance in intergroup differences and associations. ROC analysis showed DaT View striatal SBR of the better side (SBRbetter) as the optimal predictor (sensitivity 0.62, specificity 0.93 at cutoff: 2.03). DaTQUANT subregional analysis identified the anterior putamen as key in aspiration risk. Conclusion: Reduced SBR in DaT imaging shows potential as an indicator of aspiration risk in patients with PD. These findings can help clinicians identify patients at risk of aspiration, allowing for proactive referral for detailed evaluation.
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页数：7
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共 30 条
[21]  
Kim J.H., Jeon J., Lee Y., Kim S.M., Cheon M., Kim J.Y., Striatal dopaminergic loss and dysphagia in Parkinson disease, Clin. Nucl. Med., 48, pp. 143-149, (2023)
[22]  
Manor Y., Giladi N., Cohen A., Fliss D.M., Cohen J.T., Validation of a swallowing disturbance questionnaire for detecting dysphagia in patients with Parkinson's disease, Mov. Disord., 22, pp. 1917-1921, (2007)
[23]  
Lam K., Lam F.K., Lau K.K., Chan Y.K., Kan E.Y., Woo J., Wong F.K., Ko A., Simple clinical tests may predict severe oropharyngeal dysphagia in Parkinson's disease, Mov. Disord., 22, pp. 640-644, (2007)
[24]  
Troche M.S., Schumann B., Brandimore A.E., Okun M.S., Hegland K.W., Reflex cough and disease duration as predictors of swallowing dysfunction in Parkinson's disease, Dysphagia, 31, pp. 757-764, (2016)
[25]  
Suttrup I., Warnecke T., Dysphagia in Parkinson's disease, Dysphagia, 31, pp. 24-32, (2016)
[26]  
Redgrave, Rodriguez M., Smith Y., Rodriguez-Oroz M.C., Lehericy S., Bergman H., Agid Y., DeLong M.R., Obeso J.A., Goal-directed and habitual control in the basal ganglia: implications for Parkinson's disease, Nat. Rev. Neurosci., 11, pp. 760-772, (2010)
[27]  
Chung S.J., Yoo H.S., Oh J.S., Kim J.S., Ye B.S., Sohn Y.H., Lee P.H., Effect of striatal dopamine depletion on cognition in de novo Parkinson's disease, Parkinsonism Relat. Disorders, 51, pp. 43-48, (2018)
[28]  
Umehara T., Oka H., Nakahara A., Shiraishi T., Sato T., Matsuno H., Komatsu T., Omoto S., Murakami H., Iguchi Y., Dopaminergic correlates of orthostatic hypotension in de novo Parkinson's disease, J. Parkinsons Dis., 11, pp. 665-673, (2021)
[29]  
Sohara K., Sekine T., Tateno A., Mizumura S., Suda M., Sakayori T., Okubo Y., Kumita S.-I., Multi-atlas MRI-based striatum segmentation for 123I-FP-CIT SPECT (DAT-SPECT) compared with the bolt method and SPECT-atlas-based segmentation method toward the accurate diagnosis of Parkinson's disease/syndrome, Front. Med., 8, (2021)
[30]  
Fahn S., Oakes D., Shoulson I., Kieburtz K., Rudolph A., Lang A., Olanow C.W., Tanner C., Marek-The Parkinson Study Group K., Levodopa and the progression of Parkinson's disease, N. Engl. J. Med., 351, pp. 2498-2508, (2004)
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