Brain lipid sensing and the neural control of energy balance

被引：3

作者：

Cruciani-Guglielmacci, Celine ^{[1
]}

Le Stunff, Herve ^{[2
]}

Magnan, Christophe ^{[1
]}

机构：

[1] Univ Paris Cite, BFA, CNRS, UMR 8251, F-75013 Paris, France

[2] Univ Paris Saclay, Paris Saclay Inst Neurosci, CNRS, UMR 9197, Orsay, France

来源：

BIOCHIMIE | 2024年 / 223卷

关键词：

Hypothalamus; Triglycerides; saturated fatty acids; Lipoprotein lipase; Neuroinflammation; Ceramides; FATTY-ACID-METABOLISM; BROWN ADIPOSE-TISSUE; BETA-CELL FUNCTION; LIPOPROTEIN-LIPASE; GLUCOSE-PRODUCTION; INSULIN-SECRETION; NERVOUS-SYSTEM; RECEPTOR GPR40; KETONE-BODIES; FOOD-INTAKE;

D O I：

10.1016/j.biochi.2024.05.020

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The central nervous system continuously detects circulating concentrations of lipids such as fatty acids and troglycerides. Once information has been detected, the central nervous system can in turn participate in the control of energy balance and blood sugar levels and in particular regulate the secretion and action of insulin. Neurons capable of detecting circulating lipid variations are located in the hypothalamus and in other regions such as the nucleus accumbens, the striatum or the hippocampus. An excess lipids will have deleterious effects and may induce central lipotoxicity, in particular following local production of ceramides and the appearance of neuroinflammation which may lead to metabolic diseases such as obesity and type 2 diabetes. (c) 2024 Elsevier B.V. and Soci & eacute;t & eacute; Fran & ccedil;aise de Biochimie et Biologie Mol & eacute;culaire (SFBBM). All rights reserved, including those for text and data mining, AI training, and similar technologies.

引用

页码：159 / 165

页数：7

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