Lipoprotein(a) Levels and the Risk of Coronary Heart Disease and Stroke: The Suita Study

被引：0

作者：

Arafa, Ahmed ^{[1
,2
]}

Kato, Yuka ^{[1
,3
]}

Kokubo, Yoshihiro ^{[1
]}

Khairan, Paramita ^{[1
,4
]}

Matsumoto, Chisa ^{[1
,5
]}

Nakao, Yoko M. ^{[1
]}

Kataoka, Yu ^{[6
]}

Harada-Shiba, Mariko ^{[7
]}

机构：

[1] Natl Cerebral & Cardiovasc Ctr, Dept Prevent Cardiol, 6-1 Kishibe Shinmachi, Suita, Osaka 5648565, Japan

[2] Beni Suef Univ, Fac Med, Dept Publ Hlth, Bani Suwayf, Egypt

[3] Osaka Univ, Grad Sch Med, Div Hlth Sci, Suita, Japan

[4] Univ Muhammadiyah Jakarta, Fac Med, Dept Internal Med, Jakarta, Indonesia

[5] Tokyo Med Univ Hosp, Ctr Hlth Surveillance & Prevent Med, Dept Cardiol, Tokyo, Japan

[6] Natl Cerebral & Cardiovasc Ctr, Dept Cardiol, Osaka, Japan

[7] Osaka Med & Pharmaceut Univ, Cardiovasc Ctr, Osaka, Japan

来源：

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS | 2025年

关键词：

Coronary heart disease; Lipoprotein(a); Prospective cohort study; Stroke; CARDIOVASCULAR-DISEASE; ELEVATED LIPOPROTEIN(A); CHOLESTEROL; INSIGHTS; JAPANESE;

D O I：

10.5551/jat.65437

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Aims: Lipoprotein(a) (Lp[a]) exhibits atherogenic and thrombogenic properties. We investigated the association between Lp(a) levels and the risk of coronary heart disease (CHD) and stroke. Methods: We used data from 5138 people >= 30 years old registered in the Suita Study, a Japanese population-based prospective cohort study. All participants were initially free from CHD or stroke. Cox proportional hazard models were applied to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for CHD and stroke among participants with elevated Lp(a) levels. Results: At baseline, only 17.0% of participants had Lp(a) levels >= 30 mg/dL. Within the median follow-up period of 11.7 years, 164 CHD and 234 stroke events were detected. In the multivariable-adjusted regression model, Lp(a) >= 30 mg/dL was associated with an increased risk of CHD (HR, 1.52 [95% CI, 1.05-2.21]). Every 10-ml/dL increment in Lp(a) level was associated with a 7.9% increase in CHD risk. The association with CHD did not change significantly after adjusting for total cholesterol level or lipid-lowering drugs. In contrast, increased Lp(a) levels were not associated with stroke risk or any subtype. Conclusions: Lp(a) >= 30 mg/dL was associated with an increased risk of CHD in the Japanese population.

引用

页数：11