White matter integrity and motor function: a link between cerebral myelination and longitudinal changes in gait speed in aging

被引:0
|
作者
Gong, Zhaoyuan [1 ]
Faulkner, Mary E. [1 ]
Akhonda, Mohammad A. B. S. [1 ]
Guo, Alex [1 ]
Bae, Jonghyun [1 ]
Laporte, John P. [1 ]
Church, Sarah [2 ]
D'Agostino, Jarod [2 ]
Bergeron, Jan [2 ]
Bergeron, Christopher M. [2 ]
Ferrucci, Luigi [3 ]
Bouhrara, Mustapha [1 ]
机构
[1] NIA, Lab Clin Invest, NIH, BRC 05C-222,251 Bayview Blvd, Baltimore, MD 21224 USA
[2] NIA, Clin Res Core, NIH, Baltimore, MD 21224 USA
[3] NIA, Translat Gerontol Branch, NIH, Baltimore, MD 21224 USA
关键词
Gait speed; Myelin; White matter; Magnetic resonance imaging; Motor function; Longitudinal data; LOWER-EXTREMITY FUNCTION; PHYSICAL PERFORMANCE; WATER FRACTION; OLDER-ADULTS; DIFFUSION; DECLINE; BALANCE; HEALTH; RELAXATION; DISABILITY;
D O I
10.1007/s11357-024-01392-w
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Gait speed is a robust health biomarker in older adults, correlating with the risk of physical and cognitive impairments, including dementia. Myelination plays a crucial role in neurotransmission and consequently affects various functions, yet the connection between myelination and motor functions such as gait speed is not well understood. Understanding this link could offer insights into diagnosing and treating neurodegenerative diseases that impair mobility. This study analyzed 437 longitudinal observations from 138 cognitively unimpaired adults, aged 22 to 94 years, to investigate the relationship between myelin content and changes in gait speed over an average of 6.42 years. Myelin content was quantified using a novel multicomponent magnetic resonance relaxometry method, and both usual and rapid gait speeds (UGS, RGS) were measured following standard protocols. Adjusting for covariates, we found a significant fixed effect of myelin content on UGS and RGS. Longitudinally, lower myelin content was linked to a greater decline in UGS, particularly in brain regions associated with motor planning. These results suggest that changes in UGS may serve as a reliable marker of neurodegeneration, particularly in cognitively unimpaired adults. Interestingly, the relationship between myelin content and changes in RGS was only observed in a limited number of brain regions, although the reason for such local susceptibility remains unknown. These findings enhance our understanding of the critical role of myelination in gait performance in unimpaired adults and provide evidence of the interconnection between myelin content and motor function impairment.
引用
收藏
页数:14
相关论文
共 50 条
  • [1] Cerebral white matter myelination is associated with longitudinal changes in processing speed across the adult lifespan
    Gong, Zhaoyuan
    Bilgel, Murat
    An, Yang
    Bergeron, Christopher M.
    Bergeron, Jan
    Zukley, Linda
    Ferrucci, Luigi
    Resnick, Susan M.
    Bouhrara, Mustapha
    BRAIN COMMUNICATIONS, 2024, 6 (06)
  • [2] Longitudinal assessment of changes in cerebral white matter integrity in MOGAD patients
    Mewes, D.
    Juenger, V.
    Raman, M.
    Sahin, I. A.
    Duchow, A.
    Paul, F.
    Chien, C.
    MULTIPLE SCLEROSIS JOURNAL, 2022, 28 (3_SUPPL) : 806 - 807
  • [3] CHANGES IN NEUROGLIA AND MYELINATION IN WHITE MATTER OF AGING MICE
    STURROCK, RR
    JOURNALS OF GERONTOLOGY, 1976, 31 (05): : 513 - 522
  • [4] Lagged Coupled Changes Between White Matter Microstructure and Processing Speed in Healthy Aging: A Longitudinal Investigation
    Oschwald, Jessica
    Merillat, Susan
    Liem, Franziskus
    Roecke, Christina
    Martin, Mike
    Jaencke, Lutz
    FRONTIERS IN AGING NEUROSCIENCE, 2019, 11
  • [5] A link between frontal white matter integrity and dizziness in cerebral small vessel disease
    Ibitoye, Richard T.
    Castro, Patricia
    Cooke, Josie
    Allum, John
    Arshad, Qadeer
    Murdin, Louisa
    Wardlaw, Joanna
    Kaski, Diego
    Sharp, David J.
    Bronstein, Adolfo M.
    NEUROIMAGE-CLINICAL, 2022, 35
  • [6] Role of aerobic fitness and aging on cerebral white matter integrity
    Marks, Bonita L.
    Madden, David J.
    Bucur, Barbara
    Provenzale, James M.
    White, Leonard E.
    Cabeza, Roberto
    Huettel, Scott A.
    IMAGING AND THE AGING BRAIN, 2007, 1097 : 171 - 174
  • [7] Motor Skill Learning Induces Changes in White Matter Microstructure and Myelination
    Sampaio-Baptista, Cassandra
    Khrapitchev, Alexandre A.
    Foxley, Sean
    Schlagheck, Theresa
    Scholz, Jan
    Jbabdi, Saad
    DeLuca, Gabriele C.
    Miller, Karla L.
    Taylor, Amy
    Thomas, Nagheme
    Kleim, Jeffrey
    Sibson, Nicola R.
    Bannerman, David
    Johansen-Berg, Heidi
    JOURNAL OF NEUROSCIENCE, 2013, 33 (50): : 19499 - 19503
  • [8] Changes in Cerebral Volume and White Matter Integrity in Adults on Hemodialysis and Relationship to Cognitive Function
    Richerson, Wesley T.
    Umfleet, Laura G.
    Schmit, Brian D.
    Wolfgram, Dawn F.
    NEPHRON, 2021, 145 (01) : 35 - 43
  • [9] Cerebral white matter changes and geriatric syndromes: Is there a link?
    Kuo, HK
    Lipsitz, LA
    JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2004, 59 (08): : 818 - 826
  • [10] The Association Between Processing Speed and White Matter Tract Myelination in Schizophrenia
    Sui, Yu
    Samsonov, Alexey
    Bertisch, Hilary
    Goff, Donald
    Lazar, Mariana
    BIOLOGICAL PSYCHIATRY, 2019, 85 (10) : S201 - S202