Advances in 4D Bioprinting: The Next Frontier in Regenerative Medicine and Tissue Engineering Applications

被引:2
作者
Abolhassani, Sareh [1 ]
Fattahi, Roya [2 ]
Safshekan, Farzaneh [3 ]
Saremi, Jamileh [4 ]
Hasanzadeh, Elham [2 ]
机构
[1] Shiraz Univ Med Sci, Sch Adv Med Sci & Technol, Shiraz 7134814336, Iran
[2] Mazandaran Univ Med Sci, Immunogenet Res Ctr, Sch Adv Technol Med, Dept Tissue Engn & Regenerat Med, Sari 4847191971, Iran
[3] Ahrar Inst Technol & Higher Educ, Dept Mech Engn, Rasht 6359141931, Iran
[4] Jahrom Univ Med Sci, Res Ctr Noncommunicable Dis, Jahrom 7154474992, Iran
关键词
4D printing; bioprinting; drug delivery; medical applications; regenerative medicine; smart biomaterials; tissue engineering; DRUG-DELIVERY; DESIGN STRATEGIES; INSULIN DELIVERY; 3D; HYDROGELS; SCAFFOLDS; FABRICATION; GRAPHENE; PH; POLYMERS;
D O I
10.1002/adhm.202403065
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
4D bioprinting is a critical advancement in tissue engineering and regenerative medicine (TERM), enabling the creation of structures that dynamically respond to environmental stimuli over time. This review investigates various fabrication techniques and responsive materials that are central to these fields. It underscores the integration of multi-material and biocomposite approaches in 4D bioprinting, which is crucial for fabricating complex and functional constructs with heterogeneous properties. Using 4D bioprinting techniques enhances the mimicry of natural tissue characteristics, offering tailored responses and improved integration with biological systems. Furthermore, this study highlights the synergy between 4D bioprinting and tissue engineering and demonstrates the technology's potential for developing tissues and organs. In regenerative medicine, 4D bioprinting's applications extend to creating smart implants and advanced drug delivery systems that adapt to the body's changes, promoting healing and tissue regeneration. Finally, the challenges and future directions of 4D bioprinting are also explored and emphasize its transformative impact on biomedical engineering and the future of healthcare.
引用
收藏
页数:26
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