Causal association between pregnancy disorders and neonatal jaundice: a two-sample Mendelian randomization study

被引：0
作者：
Wang, Yingying [1 ,2 ]
Li, Shanshan [1 ,2 ]
Lu, Jiajin [1 ,2 ]
Yuan, Tianming [1 ]
机构：
[1] Zhejiang Univ, Sch Med, Childrens Hosp, Dept Neonatol, Hangzhou 310052, Peoples R China
[2] Shaoxing Keqiao Women & Childrens Hosp, Dept Neonatol, Shaoxing, Peoples R China
来源：
TRANSLATIONAL PEDIATRICS | 2024年 / 13卷 / 12期
关键词：
Preeclampsia; gestational edema; proteinuria neonatal jaundice; gestational diabetes mellitus; Mendelian randomization (MR); HYPERBILIRUBINEMIA;
D O I：
10.21037/tp-24-335
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Background: Some studies have suggested that complications during pregnancy, such as preeclampsia, leiomyoma during pregnancy, oxytocin induction, and mode of delivery, may be risk factors for neonatal jaundice. Herein, we applied Mendelian randomization (MR) analysis to investigate a causal association between pregnancy disorders and neonatal jaundice.Methods: Data related to neonatal jaundice and pregnancy disorders (including pre-eclampsia or eclampsia, gestational diabetes, and gestational edema) were sourced from the FinnGen Consortium and Integrated Epidemiology Unit (IEU) databases. Inverse-variance weighted (IVW) was used as a main approach for data analysis, while MR-Egger, weighted median (WM), and weighted mode methods were used to validate the robustness of the results. MR-Egger regression method was applied to explore the presence of horizontal pleiotropy. MR pleiotropy residual sum and outlier (MR-PRESSO) method was used to detect potential outliers. Cochran's Q test was used to assess heterogeneity among instrumental variables (IVs); leave-one-out (LOO) analyses were used to evaluate the presence of predominant IVs. Results: The IVW approach showed that pre-eclampsia or eclampsia {odds ratio (OR) [95% confidence interval (CI)]: 0.86 (0.36-2.07), P=0.73}, gestational edema and proteinuria [OR (95% CI): 1.04 (0.62-1.74), P=0.87], and gestational diabetes mellitus [OR (95% CI): 0.95 (0.60-1.49), P=0.81] were not associated with neonatal jaundice. The MR-Egger regression results showed that horizontal pleiotropy did not affect the relationship between exposure factors and outcomes. Also, no heterogeneity was observed. The MR-PRESSO analysis showed no outliers, confirming that these data were robust.Conclusions: Our data suggested no genetic causal association between pre-eclampsia or eclampsia, gestational edema, proteinuria, gestational diabetes mellitus, and neonatal jaundice. However, further research is needed to determine if these results apply to other races
引用
收藏
页码：2193 / 2203
页数：13
相关论文
共 37 条
  • [1] Stevenson DK, Wong RJ., Newborn jaundice—an introductory overview, Pediatr Med, 4, (2021)
  • [2] Ullah S, Rahman K, Hedayati M., Hyperbilirubinemia in Neonates: Types, Causes, Clinical Examinations, Preventive Measures and Treatments: A Narrative Review Article, Iran J Public Health, 45, pp. 558-568, (2016)
  • [3] Bante A, Ahmed M, Degefa N, Et al., Neonatal jaundice and associated factors in public hospitals of southern Ethiopia: A multi-center cross-sectional study, Heliyon, 10, (2024)
  • [4] Pranty AI, Shumka S, Adjaye J., Bilirubin-Induced Neurological Damage: Current and Emerging iPSCDerived Brain Organoid Models, Cells, 11, (2022)
  • [5] Karimzadeh P, Fallahi M, Kazemian M, Et al., Bilirubin Induced Encephalopathy, Iran J Child Neurol, 14, pp. 7-19, (2020)
  • [6] McNestry C, Killeen SL, Crowley RK, Et al., Pregnancy complications and later life women's health, Acta Obstet Gynecol Scand, 102, pp. 523-531, (2023)
  • [7] Jamalzehi A, Eslahi H, Mortazavi Z, Et al., Pregnancy Complications and Their Relationship with Neonatal Complications in Mothers Referring to Healthcare Centers in South East of Iran, Health Scope, 12, (2023)
  • [8] Yu Y, Choi J, Lee MH, Et al., Maternal disease factors associated with neonatal jaundice: a case-control study, BMC Pregnancy Childbirth, 22, (2022)
  • [9] Garosi E, Mohammadi F, Ranjkesh F., The Relationship between Neonatal Jaundice and Maternal and Neonatal Factors, Iranian Journal of Neonatology, (2016)
  • [10] Jiang N, Qian L, Lin G, Et al., Maternal blood parameters and risk of neonatal pathological jaundice: a retrospective study, Sci Rep, 13, (2023)
1234