A Closer Look into Autoimmune Liver Diseases

被引:0
作者
Filipovic, Branka [1 ,2 ]
Marjanovic-Haljilji, Marija [1 ]
Blagojevic, Dragana [1 ]
Dragovic, Milica [1 ]
Krsmanovic, Emilija [1 ]
Matovic, Ana [3 ]
Panic, Natasa [1 ]
Kiurski, Stanimir [1 ]
Zagorac, Zagor [4 ]
Milanovic, Miljan [2 ,4 ]
Markovic, Olivera [2 ,5 ]
Djokovic, Aleksandra [2 ,6 ]
Glisic, Tijana [2 ,7 ]
Dragasevic, Sanja [2 ,7 ]
Popovic, Dusan [1 ,2 ]
机构
[1] Clin & Hosp Ctr Dr Dragisa Misovic Dedinje, Dept Gastroenterol, Heroja Milana Tepica 1, Belgrade 11020, Serbia
[2] Univ Belgrade, Fac Med, Dr Subotica Starijeg 8, Belgrade 11000, Serbia
[3] Clin & Hosp Ctr Dr Dragisa Misovic Dedinje, Dept Cardiol, Heroja Milana Tepica 1, Belgrade 11020, Serbia
[4] Clin & Hosp Ctr Dr Dragisa Misovic Dedinje, Clin Surg, Heroja Milana Tepica 1, Belgrade 11020, Serbia
[5] Clin & Hosp Ctr Bezanijska Kosa, Dept Hematol, Dr Zorza Matea S-N, Belgrade 11080, Serbia
[6] Clin & Hosp Ctr Bezanijska Kosa, Dept Cardiol, Dr Zorza Matea S-N, Belgrade 11080, Serbia
[7] Univ Clin Ctr Serbia, Clin Gastroenterol & Hepatol, Belgrade 11000, Serbia
关键词
autoimmune liver disease; hepatitis; primary sclerosing cholangitis; primary biliary cholangitis; PRIMARY BILIARY-CIRRHOSIS; PRIMARY SCLEROSING CHOLANGITIS; HEPATITIS; PATHOGENESIS; GENETICS; VIRUS; HLA; ASSOCIATION; EPIGENETICS; CLEARANCE;
D O I
10.3390/ijms26051863
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Autoimmune liver diseases involve a heterogeneous group of chronic inflammatory disorders, including autoimmune hepatitis, primary biliary cholangitis, and primary sclerosing cholangitis. Sometimes presented consistently as an overlapping syndrome, their pathogenesis is rather complex and has yet to be fully elucidated, despite extensive research efforts. This review article corroborates the molecular mechanisms of autoimmune liver diseases, as well as existing and potential therapeutic modalities.
引用
收藏
页数:17
相关论文
共 88 条
  • [1] Emerging drugs for the treatment of primary sclerosing cholangitis
    Abbas, Nadir
    Quraishi, Mohammad Nabil
    Trivedi, Palak
    [J]. CURRENT OPINION IN PHARMACOLOGY, 2022, 62 : 23 - 35
  • [2] Genes of the major histocompatibility complex class II influence the outcome of hepatitis C virus infection
    Alric, L
    Fort, M
    Izopet, J
    Vinel, JP
    Charlet, JP
    Selves, J
    Puel, J
    Pascal, JP
    Duffaut, M
    Abbal, M
    [J]. GASTROENTEROLOGY, 1997, 113 (05) : 1675 - 1681
  • [3] The immunobiology of primary sclerosing cholangitis
    Aron, Jonathan H.
    Bowlus, Christopher L.
    [J]. SEMINARS IN IMMUNOPATHOLOGY, 2009, 31 (03) : 383 - 397
  • [4] Up-regulation of MicroRNA-155 in Macrophages Contributes to Increased Tumor Necrosis Factor α (TNFα) Production via Increased mRNA Half-life in Alcoholic Liver Disease
    Bala, Shashi
    Marcos, Miguel
    Kodys, Karen
    Csak, Timea
    Catalano, Donna
    Mandrekar, Pranoti
    Szabo, Gyongyi
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (02) : 1436 - 1444
  • [5] Cholangiocyte pathobiology
    Banales, Jesus M.
    Huebert, Robert C.
    Karlsen, Tom
    Strazzabosco, Mario
    LaRusso, Nicholas F.
    Gores, Gregory J.
    [J]. NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2019, 16 (05) : 269 - 281
  • [6] Calcineurin Inhibitors in the Treatment of Adult Autoimmune Hepatitis: A Systematic Review
    Baven-Pronk, Martine A. M. C.
    Hew, Joffre M., Jr.
    Biewenga, Maaike
    Tushuizen, Maarten E.
    van den Berg, Aad P.
    Bouma, Gerd
    Brouwer, Johannes T.
    van Hoek, Bart
    [J]. JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY, 2022, 10 (06) : 1155 - 1166
  • [7] Bernal B.R., 2021, Transplantology, V2, P162, DOI DOI 10.3390/TRANSPLANTOLOGY2020016
  • [8] Immune responses against human papillomavirus (HPV) type 16 virus-like particles in a cohort study of women with cervical intraepithelial neoplasia II. Systemic but not local IgA responses correlate with clearance of HPV-16
    Bontkes, HJ
    de Gruijl, TD
    Walboomers, JMM
    Schiller, JT
    Dillner, J
    Helmerhorst, TJM
    Verheijen, RHM
    Scheper, RJ
    Meijer, CJLM
    [J]. JOURNAL OF GENERAL VIROLOGY, 1999, 80 : 409 - 417
  • [9] HLA-related genetic susceptibility in autoimmune hepatitis according to autoantibody profile
    Cancado, Eduardo Luiz Rachid
    Goldbaum-Crescente, Juliana
    Terrabuio, Debora Raquel B.
    [J]. FRONTIERS IN IMMUNOLOGY, 2022, 13
  • [10] Autoimmune liver disease, autoimmunity and liver transplantation
    Carbone, Marco
    Neuberger, James M.
    [J]. JOURNAL OF HEPATOLOGY, 2014, 60 (01) : 210 - 223