Recent Progress on the Synthesis, Biological Activity of Fused Pyrimidines from Azole Amines

被引：1
作者：
Zhuang, Yumeng [1 ]
Wang, Xianzhang [1 ]
Liu, Bowen [1 ]
Yao, Lei [1 ]
机构：
[1] Yantai Univ, Sch Pharm, 30 Qingquan Rd, Yantai, Shandong, Peoples R China
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 27卷 / 43期
关键词：
1,2,4-triazole amine; Pyrazole amine; Pyrimidine; Pyrozolopyrimidine; Pyrrolopyrimidine; DERIVATIVES; ANNULATION;
D O I：
10.1002/ejoc.202400446
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Fused pyrimidines are a class of heterocyclic compounds that have gained considerable interest due to their extensive biological activities and potential applications in drug development. This review article aims to provide a comprehensive overview of the latest synthetic approaches to fused pyrimidines, including Michael reactions, multicomponent reactions, metal-catalyzed reactions, photocatalytic reactions, peroxide-mediated reactions, and inverse electron demand Diels-Alder reactions. Furthermore, the biological activities of these compounds, such as their ability to combat cancer and microbial infections, are also discussed. This review article summarizes the existing literature on the synthesis and biological activity of fused pyrimidines from 2020 to 2023. We hope this review article will inspire the development of more effective and less toxic fused pyrimidine drugs with well-designed structures.
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页数：18
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