Main methods and tools for peptide development based on protein-protein interactions (PPIs)

被引：0

作者：

Baeza, Javiera ^{[1
,2
]}

Bedoya, Mauricio ^{[3
,4
]}

Cruz, Pablo ^{[2
,5
]}

Ojeda, Paola ^{[6
]}

Adasme-Carreno, Francisco ^{[3
,4
]}

Cerda, Oscar ^{[2
,5
]}

Gonzalez, Wendy ^{[1
,2
]}

机构：

[1] Univ Talca, Fac Ingn, Ctr Bioinformat Simulac & Modelado CBSM, Talca, Chile

[2] Millennium Nucleus Ion Channel Associated Dis MiNI, Santiago, Chile

[3] Univ Catolica Maule, Ctr Invest Estudios Avanzados Maule CIEAM, Vicerrectoria Invest & Postgrad, Talca, Chile

[4] Univ Catolica Maule, Fac Med, Dept Med Traslac, Lab Bioinformat & Quim Computac LBQC, Talca, Chile

[5] Univ Chile, Fac Med, Programa Biol Celular & Mol, Inst Ciencias Biomed ICBM, Santiago, Chile

[6] Univ San Sebastian, Fac Med & Ciencia, Carrera Quim & Farm, Gen Lagos 1163, Valdivia 5090000, Chile

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2025年 / 758卷

关键词：

Competitive peptides; Protein-protein interactions; In silico peptide design; In vitro peptide evaluation; CELL-PENETRATING PEPTIDES; NOVO STRUCTURE PREDICTION; WEB SERVER; CYCLIC PEPTIDE; FLUORESCENCE COMPLEMENTATION; ANTITUMOR-ACTIVITY; AUTOMATED DOCKING; MASS-SPECTROMETRY; FAMILY PROTEINS; IN-VITRO;

D O I：

10.1016/j.bbrc.2025.151623

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protein-protein interactions (PPIs) regulate essential physiological and pathological processes. Due to their large and shallow binding surfaces, PPIs are often considered challenging drug targets for small molecules. Peptides offer a viable alternative, as they can bind these targets, acting as regulators or mimicking interaction partners. This review focuses on competitive peptides, a class of orthosteric modulators that disrupt PPI formation. We provide a concise yet comprehensive overview of recent advancements in in-silico peptide design, highlighting computational strategies that have improved the efficiency and accuracy of PPI-targeting peptides. Additionally, we examine cutting-edge experimental methods for evaluating PPI-based peptides. By exploring the interplay between computational design and experimental validation, this review presents a structured framework for developing effective peptide therapeutics targeting PPIs in various diseases.

引用

页数：19

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