Peripheral and central inflammation in depression: How large is the gap and can we bridge it with PET neuroimaging and neural-derived extracellular vesicles?

被引:0
作者
Llach, Cristian-Daniel [1 ,2 ]
Le, Gia Han [1 ,3 ,4 ]
Shah, Hiya [1 ]
Marcato, Liz M. [1 ]
Brietzke, Elisa [5 ]
Gill, Hartej [1 ,3 ]
Tabassum, Aniqa [1 ,3 ]
Badulescu, Sebastian [1 ,3 ,4 ]
Rosenblat, Joshua D. [1 ,2 ,3 ]
McIntyre, Roger S. [1 ,2 ,3 ]
Mansur, Rodrigo B. [1 ,2 ,3 ]
机构
[1] Univ Hlth Network, Mood Disorders Psychopharmacol Unit, Toronto, ON, Canada
[2] Univ Toronto, Dept Psychiat, Toronto, ON, Canada
[3] Univ Toronto, Inst Med Sci, Toronto, ON, Canada
[4] Brain & Cognit Discovery Fdn, Toronto, ON, Canada
[5] Queens Univ, Sch Med, Dept Psychiat, Kingston, ON, Canada
关键词
Inflammation; Neuroinflammation; Depression; Biomarkers; Cytokines; PET neuroimaging; Extracellular vesicles; C-REACTIVE PROTEIN; BIPOLAR DISORDER; BRAIN; MICROGLIA; CYTOKINE; EXPRESSION; METAANALYSIS; STRESS; NEUROINFLAMMATION; MACROPHAGES;
D O I
10.1016/j.jneuroim.2025.578587
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Major depressive disorder (MDD) presents as a multifaceted syndrome with complex pathophysiology and variable treatment responses, posing significant challenges in clinical management. Neuroinflammation is known to play pivotal mechanism in depression, linking immune responses with central nervous system (CNS) dysfunction. This review explores the interplay between peripheral and central inflammatory processes in MDD, emphasizing discrepancies in biomarker validity and specificity. While peripheral markers like cytokines have historically been investigated as proxies for neuroinflammation, their reliability remains contentious due to inconsistent findings, lack of correlation with neuroinflammatory markers, the influence of confounding variables, and the role of regulatory mechanism within the CNS. Additionally, the human brain shows a pattern of regionalized inflammation. Current methodologies for investigating neuroinflammation in humans in vivo, including neural-derived extracellular vesicles (EVs) and positron emission tomography (PET) neuroimaging using translocator protein, offer promising avenues while facing substantial limitations. We propose that future research in MDD may benefit from combined microglia-derived EV-TSPO PET neuroimaging analyses to leverage the strengths and mitigate the limitations of both individual methods.
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页数:10
相关论文
共 136 条
[61]   Peripheral cytokine and chemokine alterations in depression: a meta-analysis of 82 studies [J].
Kohler, C. A. ;
Freitas, T. H. ;
Maes, M. ;
de Andrade, N. Q. ;
Liu, C. S. ;
Fernandes, B. S. ;
Stubbs, B. ;
Solmi, M. ;
Veronese, N. ;
Herrmann, N. ;
Raison, C. L. ;
Miller, B. J. ;
Lanctot, K. L. ;
Carvalho, A. F. .
ACTA PSYCHIATRICA SCANDINAVICA, 2017, 135 (05) :373-387
[62]   Depression and Autoimmune Hypothyroidism-Their Relationship and the Effects of Treating Psychiatric and Thyroid Disorders on Changes in Clinical and Biochemical Parameters Including BDNF and Other Cytokines-A Systematic Review [J].
Kotkowska, Zofia ;
Strzelecki, Dominik .
PHARMACEUTICALS, 2022, 15 (04)
[63]  
Krassner Margaret M, 2023, Free Neuropathol, V4, P10, DOI 10.17879/freeneuropathology-2023-4790
[64]   Impairment of Paravascular Clearance Pathways in the Aging Brain [J].
Kress, Benjamin T. ;
Iliff, Jeffrey J. ;
Xia, Maosheng ;
Wang, Minghuan ;
Wei, Helen S. ;
Zeppenfeld, Douglas ;
Xie, Lulu ;
Kang, Hongyi ;
Xu, Qiwu ;
Liew, Jason A. ;
Plog, Benjamin A. ;
Ding, Fengfei ;
Deane, Rashid ;
Nedergaard, Maiken .
ANNALS OF NEUROLOGY, 2014, 76 (06) :845-861
[65]   CORTICOTROPIN-RELEASING HORMONE, MICROGLIA AND MENTAL DISORDERS [J].
Kritas, S. K. ;
Saggini, A. ;
Cerulli, G. ;
Caraffa, A. ;
Antinolfi, P. ;
Pantalone, A. ;
Rosati, M. ;
Tei, M. ;
Speziali, A. ;
Saggini, R. ;
Conti, P. .
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, 2014, 27 (02) :163-167
[66]   Neuron-related blood inflammatory markers as an objective evaluation tool for major depressive disorder: An exploratory pilot case-control study [J].
Kuwano, Nobuki ;
Kato, Takahiro A. ;
Mitsuhashi, Masato ;
Sato-Kasai, Mina ;
Shimokawa, Norihiro ;
Hayakawa, Kohei ;
Ohgidani, Masahiro ;
Sagata, Noriaki ;
Kubo, Hiroaki ;
Sakurai, Takeshi ;
Kanba, Shigenobu .
JOURNAL OF AFFECTIVE DISORDERS, 2018, 240 :88-98
[67]   Longitudinal Association Between Depression and Inflammatory Markers: Results From the Netherlands Study of Depression and Anxiety [J].
Lamers, Femke ;
Milaneschi, Yuri ;
Smit, Johannes H. ;
Schoevers, Robert A. ;
Wittenberg, Gayle ;
Penninx, Brenda W. J. H. .
BIOLOGICAL PSYCHIATRY, 2019, 85 (10) :829-837
[68]   Distinct Features of Brain-Resident Macrophages: Microglia and Non-Parenchymal Brain Macrophages [J].
Lee, Eunju ;
Eo, Jun-Cheol ;
Lee, Changjun ;
Yu, Je-Wook .
MOLECULES AND CELLS, 2021, 44 (05) :281-291
[69]  
Liu HY, 2018, ONCOTARGET, V9, P2887, DOI [10.18632/oncotarget.20812, 10.18632/oncotarget.23208]
[70]   Glial Cell Abnormalities in Major Psychiatric Diseases: A Systematic Review of Postmortem Brain Studies [J].
Liu, Shu-Han ;
Du, Yang ;
Chen, Lei ;
Cheng, Yong .
MOLECULAR NEUROBIOLOGY, 2022, 59 (03) :1665-1692