Loss of trabecular meshwork stem cells is correlated with open angle glaucoma

被引：0
作者：
Brumley, Sarah [1 ,2 ]
Xian, Shuyu [1 ,2 ]
Kuehn, Markus H. [1 ,2 ]
机构：
[1] Univ Iowa, Dept Ophthalmol & Visual Sci, Iowa City, IA 52242 USA
[2] Iowa City VA Ctr Prevent & Treatment Visual Loss, Iowa City, IA 52246 USA
来源：
EXPERIMENTAL EYE RESEARCH | 2025年 / 253卷
关键词：
Trabecular meshwork; Stem cells; Intraocular pressure; Glaucoma;
D O I：
10.1016/j.exer.2025.110296
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
The trabecular meshwork (TM) of the eye is critical in maintaining aqueous humor outflow and intraocular pressure (IOP). The cellular density in the TM decreases with age and is particularly low in eyes with glaucoma. TM cells are thought to be derived from a population of stem cells, referred to as TM stem cells (TMSCs). To investigate the relationship between TM cellular density and TMSCs, the number of TMSCs and TM cells was compared in human eyes obtained from young donors, individuals with glaucoma, and age-matched controls. Findings obtained confirm that eyes of younger donors contain the largest number of TM cells, while those of older healthy donors contained more TM cells than glaucomatous eyes of the same age (p = 0.0007). Likewise, we detected the largest number of TMSCs in young eyes, significantly higher than in healthy older eyes (p < 0.0001). Again, eyes from glaucomatous patients contained fewer TMSC than those of healthy donors (p < 0.0001). Together the data indicate a clear decline in the number of TMSCs with age and a further reduction in eyes with glaucoma. Although this study does not establish causality, our finding is consistent with the notion that the degeneration or loss of stemness of TMSCs is the cause of reduced TM cellularity which, in turn, is associated with TM dysfunction and the development of elevated IOP.
引用
收藏
页数：4
相关论文
共 21 条
  • [1] Abu-Hassan D.W., Acott T.S., Kelley M.J., The trabecular meshwork: a basic review of form and function, J. Ocul. Biol., 2, (2014)
  • [2] Acott T.S., Samples J.R., Bradley J.M., Bacon D.R., Bylsma S.S., Van Buskirk E.M., Trabecular repopulation by anterior trabecular meshwork cells after laser trabeculoplasty, Am. J. Ophthalmol., 107, pp. 1-6, (1989)
  • [3] Alvarado J., Murphy C., Juster R., Trabecular meshwork cellularity in primary open-angle glaucoma and nonglaucomatous normals, Ophthalmology, 91, pp. 564-579, (1984)
  • [4] Anderson D.R., The development of the trabecular meshwork and its abnormality in primary infantile glaucoma, Trans. Am. Ophthalmol. Soc., 79, pp. 458-485, (1981)
  • [5] Braunger B.M., Ademoglu B., Koschade S.E., Fuchshofer R., Gabelt B.T., Kiland J.A., Hennes-Beann E.A., Brunner K.G., Kaufman P.L., Tamm E.R., Identification of adult stem cells in Schwalbe's line region of the primate eye, Investig. Ophthalmol. Vis. Sci., 55, pp. 7499-7507, (2014)
  • [6] Bylsma S.S., Samples J.R., Acott T.S., Van Buskirk E.M., Trabecular cell division after argon laser trabeculoplasty, Arch. Ophthalmol., 106, pp. 544-547, (1988)
  • [7] Cvekl A., Tamm E.R., Anterior eye development and ocular mesenchyme: new insights from mouse models and human diseases, Bioessays, 26, pp. 374-386, (2004)
  • [8] Ding X.W., Wu J.H., Jiang C.P., ABCG2: a potential marker of stem cells and novel target in stem cell and cancer therapy, Life Sci., 86, pp. 631-637, (2010)
  • [9] Grierson I., Howes R.C., Age-related depletion of the cell population in the human trabecular meshwork, Eye (Lond), 1, pp. 204-210, (1987)
  • [10] Kuehn M.H., Vranka J.A., Wadkins D., Jackson T., Cheng L., Ledolter J., Circumferential trabecular meshwork cell density in the human eye, Exp. Eye Res., 205, (2021)
123