MicroRNA-155 rs767649 polymorphism is associated with susceptibility to peri-implantitis

被引：0

作者：

Fu, Hao ^{[1
]}

Li, Xiangrong ^{[2
]}

Xie, Zeneng ^{[3
]}

Jiang, Yinhua ^{[4
]}

Qin, Huiling ^{[5
]}

机构：

[1] Xinxiang Med Univ & Dent technol, Sch Sanquan Coll, Xinxiang 453003, Peoples R China

[2] Northern Jiangsu Peoples Hosp, Dept Neurol, Yangzhou 225001, Peoples R China

[3] Zhejiang Chinese Med Univ, Sch Stomatol, Hangzhou 310053, Peoples R China

[4] Wenzhou Med Univ, Lishui Peoples Hosp, Dept Radiol, Affiliated Hosp 6, Lishui 323000, Peoples R China

[5] Youjiang Med Univ Nationalities, Dept Rehabil, Affiliated Hosp, Baise 533000, Peoples R China

来源：

ARCHIVES OF ORAL BIOLOGY | 2025年 / 173卷

关键词：

MicroRNA-155; Polymorphism; Peri-implantitis; MIR-155; DIFFERENTIATION; CLASSIFICATION; EXPRESSION;

D O I：

10.1016/j.archoralbio.2025.106219

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Objective: To examine how the miR-155 rs767649 polymorphism affects miR-155 expression and to investigate its association with peri-implantitis susceptibility. Design: One hundred and eighty-seven peri-implantitis patients and 196 healthy implant subjects were enrolled. The expression level of miR-155 in the subjects' serum was tested using qRT-PCR. The rs767649 polymorphism was genotyped with the TaqMan SNP genotyping assay. The genotype and allele distributions of miR-155 rs767649 polymorphism were compared between the case and control groups. Target genes of miR-155 were predicted using four online databases (ENCORI, miRDB, miRWalk and TargetScan). Functions and pathways of these target genes were annotated through GO and KEGG enrichment. Results: The qRT-PCR results revealed that miR-155 was upregulated in patients with peri-implantitis (P < 0.001) based on Student's t test analysis. Carriers of the rs767649 TT genotype had higher levels of miR-155 expression in their serum (P < 0.001) and a greater risk of peri-implantitis compared to those with the TA/AA genotype according to the chi-square test results (P = 0.016). The downstream target genes of miR-155 may be involved in pathways such as Kaposi sarcoma-associated herpesvirus infection, ubiquitin-protein hydrolysis, and cell differentiation. Conclusion: The results revealed a correlation between the miR-155 rs767649 polymorphism and susceptibility to peri-implantitis. The rs767649 TT genotype upregulates miR-155 expression, which regulates downstream signaling pathways and increases the chance of peri-implantitis.

引用

页数：7