Concurrent Association of Multifocality, Bilaterality, and Recurrence in Pediatric Papillary Thyroid Cancer Patients

被引：0

作者：

Cho, Jae Won ^{[1
]}

Rah, Cheong-Sil ^{[6
]}

Kim, Won Woong ^{[1
]}

Lee, Yu-mi

Kim, Seong Chul ^{[2
]}

Baek, Jung Hwan ^{[3
]}

Song, Dong Eun ^{[4
]}

Kim, Won Gu ^{[5
]}

Chung, Ki-Wook ^{[1
]}

Hong, Suck Joon ^{[6
]}

Sung, Tae-Yon ^{[1
]}

机构：

[1] Univ Ulsan, Asan Med Ctr, Med Ctr, Dept Surg, Seoul, South Korea

[2] Univ Ulsan, Asan Med Ctr, Med Ctr, Dept Pediat Surg, Seoul, South Korea

[3] Univ Ulsan, Asan Med Ctr, Med Ctr, Dept Radiol, Seoul, South Korea

[4] Univ Ulsan, Asan Med Ctr, Med Ctr, Dept Pathol, Seoul, South Korea

[5] Univ Ulsan, Asan Med Ctr, Med Ctr, Dept Internal Med, Seoul, South Korea

[6] Eulji Univ, Uijeongbu Eulji Med Ctr, Dept Surg, Uijongbu, South Korea

来源：

YONSEI MEDICAL JOURNAL | 2025年 / 66卷 / 01期

关键词：

Pediatric papillary thyroid cancer; multifocality; bilaterality; recurrence; MANAGEMENT GUIDELINES; SURGICAL-MANAGEMENT; ADULT PATIENTS; CHILDREN; CARCINOMA; CHILDHOOD; ADOLESCENTS; NODULES; LOBECTOMY; DISEASE;

D O I：

10.3349/ymj.2023.0582

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose: Pediatric papillary thyroid cancer (PTC) is recommended to perform aggressive surgery to reduce the risk of recurrence. This study was designed to evaluate the concurrent association between multifocality, bilaterality, and the risk of recurrence in pediatric PTC. Materials and Methods: This retrospective cohort study included pediatric patients (age <19 years) who underwent total thyroidectomy for PTC between 1996 and 2014 in a single tertiary center. Clinicopathological parameters were analyzed to evaluate the prevalence of multifocality, bilaterality, recurrence, and their association. Results: We analyzed 58 pediatric patients with PTC. There was no factor related to the presence of multifocality or bilaterality in multivariate analysis. Also, in univariate analysis, multifocality and bilaterality were not independent risk factors of each other's presentation (p=0.061 and p =0.061, respectively). Recurrence was observed in 19 (32.8%) patients. In multivariate analysis of recurrence, clear cell subtype, multifocality, and gross extrathyroidal extension (ETE) were independent risk factors (p=0.027, p =0.035, and p =0.038, respectively). Most recurrences (68.4%) happened during the first 4 years of follow-up after the initial thyroidectomy. Conclusion: Multifocality and bilaterality were not independent risk factors of each other's presentation; however, multifocality was the risk factor for recurrence in pediatric PTC. For pediatric PTC, close monitoring for recurrence within the initial 4 years is recommended, particularly in patients with clear cell subtype, multifocality, and gross ETE.

引用

页码：43 / 50

页数：8

共 30 条

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