Arechuines A-D, arecoline alkaloids from the peels of Areca catechu L.

被引：0

作者：

Sun, Biao ^{[1
]}

Wu, Yuanning ^{[1
]}

Yang, Jianzhan ^{[2
]}

Zhang, Shiqing ^{[1
]}

Xu, Fangfang ^{[2
]}

Zhang, Xiaoqi ^{[1
]}

机构：

[1] Jinan Univ, Coll Pharm, Guangdong Prov Engn Res Ctr Modernizat TCM, NMPA Key Lab Qual Evaluat TCM, Guangzhou, Peoples R China

[2] Guangzhou Univ Chinese Med, Clin Coll 2, Guangdong Prov Key Lab Res Emergency TCM, Guangzhou, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2025年

基金：

中国国家自然科学基金;

关键词：

Areca catechu L; arecoline alkaloids; structure elucidation; antiepileptic activity; neuroprotective effects; BETEL NUT; GABA;

D O I：

10.1080/14786419.2025.2455460

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Four novel arecoline alkaloid atropisomers, arechuines A-D (1 - 4), were obtained from the peels of Areca catechu L. Their structures were elucidated by UV, IR, MS and NMR spectra. The absolute configurations of (+)/(-)-4 were determined by comparing the experimental and calculated ECD spectra. Compounds 1 - 4 were evaluated for their neuroprotective effects in glutamate-induced HT22 cell and 3 revealed potent neuroprotective effects at 10 mu M. These are the first reported arecoline alkaloid atropisomers isolated from A. catechu.

引用

页数：8