Arechuines A-D, arecoline alkaloids from the peels of Areca catechu L.

被引：0

作者：

Sun, Biao ^{[1
]}

Wu, Yuanning ^{[1
]}

Yang, Jianzhan ^{[2
]}

Zhang, Shiqing ^{[1
]}

Xu, Fangfang ^{[2
]}

Zhang, Xiaoqi ^{[1
]}

机构：

[1] Jinan Univ, Coll Pharm, Guangdong Prov Engn Res Ctr Modernizat TCM, NMPA Key Lab Qual Evaluat TCM, Guangzhou, Peoples R China

[2] Guangzhou Univ Chinese Med, Clin Coll 2, Guangdong Prov Key Lab Res Emergency TCM, Guangzhou, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2025年

基金：

中国国家自然科学基金;

关键词：

<italic>Areca catechu</italic> L; arecoline alkaloids; structure elucidation; antiepileptic activity; neuroprotective effects; BETEL NUT; GABA;

D O I：

10.1080/14786419.2025.2455460

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Four novel arecoline alkaloid atropisomers, arechuines A-D (1 - 4), were obtained from the peels of Areca catechu L. Their structures were elucidated by UV, IR, MS and NMR spectra. The absolute configurations of (+)/(-)-4 were determined by comparing the experimental and calculated ECD spectra. Compounds 1 - 4 were evaluated for their neuroprotective effects in glutamate-induced HT22 cell and 3 revealed potent neuroprotective effects at 10 mu M. These are the first reported arecoline alkaloid atropisomers isolated from A. catechu.

引用

页数：8

共 23 条

[1] Volatile alkaloids from Areca catechu
Holdsworth, DK
Jones, RA
Self, R
PHYTOCHEMISTRY, 1998, 48 (03) : 581 - 582
[2] In vitro anti-HSV1 activity of aqueous extract of Areca catechu L.
Zamanian, Mahsa
Asgari, Emad
Afaridoon, Sahar
Akbarzadeh, Tahmineh
Sharifi, Zohreh
Saeedi, Mina
IRANIAN JOURNAL OF MICROBIOLOGY, 2024, 16 (02) : 251 - 257
[3] Plant regeneration through somatic embryogenesis from zygotic embryo-derived callus of Areca catechu L. (Arecaceae)
Hsiang-Chih Wang
Jen-Tsung Chen
Shieh-Ping Wu
Mei-Chun Lin
Wei-Chin Chang
In Vitro Cellular & Developmental Biology - Plant, 2003, 39 : 34 - 36
[4] Plant regeneration through somatic embryogenesis from zygotic embryo-derived callus of Areca catechu L. (Arecaceae)
Wang, HC
Chen, JT
Wu, SP
Lin, MC
Chang, WC
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-PLANT, 2003, 39 (01) : 34 - 36
[5] Technologic parameter optimization in pilot-scale process of heat pump drying of Areca catechu L.
Zhang R.
Gao Y.
Feng J.
Xie H.
Deng H.
Zhuang G.
Dou Z.
Nongye Gongcheng Xuebao/Transactions of the Chinese Society of Agricultural Engineering, 2016, 32 (09): : 241 - 247
[6] Stephtetrandrine A-D, bisbenzylisoquinoline alkaloids from Stephania tetrandra
Yang, Li-Jun
Yang, Zhong-Duo
Li, Zhi-Jie
Yang, Shu-Hong
Shu, Zong-Mei
NATURAL PRODUCT RESEARCH, 2023, 37 (02) : 204 - 215
[7] Betel nut (Areca catechu L.) extract toxicity on the kidney and liver of white rats (Rattus norvegicus)
Arjana, A. A. Gde
Sukada, I. Made
Suratma, N. Adi
BALI MEDICAL JOURNAL, 2019, 8 (02) : 444 - 448
[8] Clinico-Immunochemical Studies on Airborne Areca catechu L. Pollen, a Probable Risk Factor in Emergency Asthma Hospitalization from Eastern India
Chakraborty, Pampa
Mandal, Jyotshna
Sarkar, Eva
Chowdhury, Indrani
Gupta-Bhattacharya, Swati
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2009, 149 (04) : 305 - 314
[9] Green Flow Injection Spectrophotometry with Betel Nut (Areca catechu L.) Natural Reagent for Indirect Determination of Ascorbic Acid
Sam-ang Supharoek
Bordin Weerasuk
Kate Grudpan
Kraingkrai Ponhong
Journal of Analytical Chemistry, 2022, 77 : 1274 - 1281
[10] Kopsileuconines A-D: Bisindole alkaloids with cytotoxic activity from Kopsia hainanensis
Li, Ni-Ping
Chen, Shan-Na
Su, Wei-Fang
Liu, Fen
Li, Lian-Jing
Song, Jian-Guo
Cheng, Min-Jing
Li, Yi-Yi
Chen, Run-Qiang
Lei, Xue-Ping
Ye, Wen-Cai
Wang, Lei
PHYTOCHEMISTRY, 2024, 228

← 1 2 3 →